六味地黄丸或金匮肾气丸辅助治疗小细胞肺癌的疗效观察——附六味地黄汤及金匮肾气汤对小鼠免疫功能的影响

作者	单位
刘叙仪	北京市肿瘤研究所内科
庞玉滨	北京市肿瘤研究所内科
赵玉亮	北京市肿瘤研究所内科
王红	北京市肿瘤研究所内科
王耐勤	北京市肿瘤研究所药理科
孔家军	北京市肿瘤研究所中医科

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中文摘要:

74例小细胞肺癌(SCLC),随机分组,于化、放疗中并用金匮肾气丸或六味地黄丸。中药组总有效率(完全缓解加部分缓解)、中数生存期(MST)及 Kapean-meier生存期曲线均明显优于对照组。中药组4例现已达77～108月仍健在,对照组1例完全缓解已达94月。同期小鼠动物实验示:两药均有显著提高体液及细胞免疫作用。

英文摘要:

Eighty-three patients with small cell luug cancer were randomized with or witbout using a traditional Chinese Kidney-tonifying decoction(Liu Wei Di Huang or Jin Gui Shen Qi medicinal. decoction)in chemotherapy or radiotherapy courses.74 patients were aviable to be analysis.The two treatment groups were well-matched in age,sex,stage and preformance status.There was a statistically significant dlfference in response rate and the median survival between two groups.The overall response rate(CR+PR)was 91.5% for Chinese herb group and 46.9% for control group(P< 0.001).The median survival was 16 months for the traditional Chinese Kidney-tonifying decoction group,and 10 months for the control group(P<0.05).Survival curve(Kaplan-meire’s)of the Chinese herb group was better than that of the control group.10 patients of Chinese herb group was alive beyoned more than 2 years.Until now,4 patients in the Chinese herb group,one in the control group are still enjoying their disease-free life for more than 7 years.Hematologic toxicities were observed much frequently in the patients of the control group(P<0.005 and 0.01/WBC and BPC). Results of animal experiments with the same traditional medicinal decoctions as used in clinic have showed immuno-enhancement activities.These results have showed that the traditional Chinese Kidney-tonifying decoction may enhance non-specific immunology activities and may be much useful for solid cancer patients as an adjuvant treatment.

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