青蒿素及其衍生物免疫抑制作用的实验研究

作者	单位
孙秀珍	长春职工医科大学
谢蜀生	北京医科大学免疫学教研室
龙振洲	北京医科大学免疫学教研室
张文仁	北京医科大学免疫学教研室
屠呦呦	中国中医研究院中药研究所

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中文摘要:

本实验研究了青蒿素(QHS)及青蒿素衍生物(DQHS)的免疫调节作用,结果表明,经腹腔注射25～100mg/kg 剂量的 QHS 及 DQHS 都能明显地抑制小鼠抗体分泌细胞(PFC)数。在100mg/kg 剂量下,QHS 及 DQHS 能明显抑制牛血清白蛋白(BSA)诱导的小鼠迟发型超敏反应(DTH);抑制小鼠脾细胞对 ConA 及 LPS 的增殖反应;抑制小鼠脾细胞产生白细胞介素-2(IL-2)这些结果表明,青蒿素及其衍生物对小鼠体液免疫和细胞免疫均有明显的抑制作用。

英文摘要:

In this report the researchers studied the immunosuppressive effects of Qinghaosu(QHS)and its derivative(DQHS).The results indicated that after 7-day successive administration i.p of QHS and DQHS at the dosage of 25～100 mg/kg,the amounts of anti-SRBC IgM PFC and IgG PFC in the murine spleen were decreased significantly(P<0.01).At the dosage of 100 mg/kg the QHS and DQHS were able to inhibit the DTH induced with BSA and the proliferative responses of murine apleen cells to Con A and LPS.These results suggested the suppressive effects of QHS and DQHS on both humoral and cellular immunities of mice.Interleukin-2(IL-2)is an inportant mediate in the immune response and plays a critical role in the activation and differentiation of T and B lymphocytes.The results in this report showed a significant suppression of IL-2 production of mourine spleen cells after 7-day administration i.p of QHS and DQHS,which suggested that the inhibition of IL-2 production could be the important one of the mechanisms of the immunosuppressive effects of QHS and DQHS.

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