滋阴、助阳药对“高甲”、“低甲”大鼠模型肝细胞核甲状腺激素受体的影响

Effects of Yin(阴)-Tonics and Yang(阳)-Tonics on Serum Thyroid Hormone Levels and Thyroid Hormone Receptors of Hepatic Cell Nucleus in Hyperthyroxinemic and Hypothyroxinemic Rats

免费下载全文查看/发表评论下载PDF阅读器

DOI：

中文关键词: 肝细胞核甲状腺激素甲状腺激素受体滋阴药助阳药

英文关键词:hepatic cell nucleus thyroid hormone receptor Yin tonics Yang tonics

基金项目:

作者	单位
张家庆	第二军医大学长海医院内分泌科
赵明	解放军八一医院内分泌科

摘要点击次数: 1452

全文下载次数: 986

中文摘要:

本实验用已建立的肝细胞核甲状腺激素受体（T₃R）测定法,观察3组中药对"高甲"和"低甲"模型大鼠 T₃R 和甲状腺激素的影响。结果发现滋阴药（生地、玉竹）能降低"高甲"模型血清甲状腺激素水平,同时也降低肝细胞核已升高的 T₃R 的最大结合量（Bmax）,使之接近正常。助阳药Ⅰ（附子、肉桂）能升高"低甲"模型血清甲状腺激素水平,但反而降低T₃R 的 Bmax。助阳药Ⅱ（仙灵脾、苁蓉）也升高血清甲状腺激素水平,但对 T₃R 的 Bmax 无显著影响。这3组中药对 T₃R 的 Kd 均无影响。

英文摘要:

Hyperthyroxinemia model was made by giving thyroid tablet suspension to Wistar rats and hypothyroxinemia model was made by thyroidectomy.We measured serum thyroid hormone levels by RIA and the parameters of triiodothyronine receptors in rat hepatic cell nucleus by radio-ligand binding assay:Maximal binding capacity（Bmax）and Dissociation constant（Kd）.It is found that（1） Yin-tonics can lower serum thyroid hormone levels and Bmax of hepatic nuclear T₃R of hyperthyrox- inemia rat from 167.14±25.62 fmol/100 μg DNA to 98.98±15.24 fmol/100 μg DNA,P<0.001.（2）Both Yang-tonics Ⅰ and Ⅱ can raise serum thyroid hormone levels of hypothyroxinemia rats,but not Bmax of hepatic nuclest T₃R.Yang-tonics Ⅰ even lowers Bmax.All the Chinese herbs have no effect on the Kd of rat hepatic nuclear T₃R.The results may have some value in studying the effects of Chinese medical drugs.

关闭