肠梗阻家兔血管活性肠肽改变及大承气汤对其的影响

作者	单位
尤胜义	天津医学院附属医院
杜宝恒	天津医学院附属医院
马丽云	天津市内分泌研究所
吴咸中	天津医学院
张集圣	天津医学院

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中文摘要:

本实验首次证明人工塑造小肠梗阻家兔动脉血中血管活性肠肽(VIP)高于梗阻前7.9倍,十二指肠组织 VIP 增加1倍。十二指肠灌注大承气汤后,血浆 VIP 含量下降50%,对照组升高65%。门脉血 VIP 含量为动脉血的4倍,其改变趋势与动脉血相似。VIP 增高是肠梗阻时导致肠壁充血、水肿及肠腔渗液增加等病理改变的重要因素之一,大承气汤对其有治疗作用,该方剂对生理和病理状态下的 VIP 水平表现为双向调节作用。

英文摘要:

The role of vasoactive intestinal polypeptide(VIP)in small intestine obstructed rabbits and the therapeutic mechanism of Da Cheng Oi Decoction(DCQD)were studied.VIP concentrations of both blood and intestinal tissue were measured by specific radio-immunoassay in a rabbis’mechanical small intestianl obstruction model using fix of ileum to the right low abdominal wall,the influences of duodenal perfusion of DCQD on VIP levels were also investigated.24 hours after ligating ileum, VIP of arterial plasma was elevated 7 fold,reaching 138.65±25.58 pmol/L,that of portal vein plasma was 4 times of the arterial value.VIP immunoactivity was detected in peritoneal fluid.VIP content of duodenal tissue in 16 intestine obstructed rabbits was 2 times high as that in 15 controls,whereas that of colonal tissue was inversed.DCQD caused a 50% decrease of elevated plasma VIP in experimental animals and a 65% increase in controls. The present work demonstrates that VIP might be reIeased into the portal and peripheral circulation and mediate local and systemic pathophysiologic alterations accompanying small intesti- nal obstruction,such as hyperemia and edema of intestinal wall,accumulation of fluid in the lumen. VIP changes might account for the redistribution of blood flow in the obstructed segment of small intestine and the distal site of obstruction.DCQD has a therapeutic effect.The mechanism of dual modulate action of DCQD on VIP concentration is beyond our knowledge.

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