赤芍注射液治疗慢性肺心病、肺动脉高压的临床研究

本研究用心肺阻抗血流图、血液粘度检查,动脉血气分析以及右心导管术等方法比较观察了42例肺心病患者静脉、肺动脉注射100%赤芍液的临床疗效。结果显示:赤芍注射液能扩张肺血管、降低肺动脉压力和肺血管阻力,增加心输出量,改善右心功能和血液流变性,提高氧分压,使临床瘀血体征显著改善,是防治肺心病、肺动脉高压较为适用的中药制剂。

英文摘要:

The changes of clinical features of blood stasis,hemorheology,arterial blood gas and hemodynamics which was determined by impedance cardiogram and pheopneumogram,hemor- heologic examination,blood gaseous analysis and right heart catheterization were observed in 42 patients（male 35,female 7;age 64±16.5 years）,32 patients with decompensative chronic cor pulmonal（CCP）.served as noninvasive methods group（NMG）treated by intravenous injecting 100% Paeonia lactifiora injection 5 ml per day,10 patients with CCP as well aspulmonary hypertension, which was proved through right heart catheterization were considered as invasive methods group （IMG）treated by pulmonary artery injecting 100% Paeonia lactiflora 5 ml（one time）.After the treatment,the clinical features of blood stasis were improved significantly in NMG（P<0.05）.Also the results of impedance cardiogram and pheopneumogram（such as:Q-B,B-Yinterval and Q-B/B-Y ratio,cardiac output）,the hemorheologic parameters（such as:blood viscosity,plasma viscosity, hematoerit and erythrocyte electrophoresis）and oxygen consumption of myocardium were im- provecd significantly in NMG and IMG.In IMG,PAP was reduced by 0.71±0.27 kPa;PaO₂ was promoted significantly in NMG.All of these have statistical significance（P<0.05 or 0.01）.There are no statistical significance about the change of PaCO₂,SaO₂,blood pH and Bp（P<0.05）.

关闭