骨科创伤患者T细胞亚群变化及一盘珠汤对其免疫调节作用

作者	单位
万圣祥	同济医科大学附属协和医院骨伤科研究室
杨家玉	同济医科大学附属协和医院骨伤科研究室
沈霖	同济医科大学附属协和医院骨伤科研究室
刘绍春	同济医科大学病理解剖学教研室

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中文摘要:

本实验采用间接免疫荧光法对40例骨科创伤患者外周静脉血 T 细胞亚群进行检测,且动态观察了中药一盘珠汤对创伤后 T 细胞亚群的免疫调节作用。结果显示:创伤后24h 内总 T 细胞百分率下降,Th 细胞百分率无明显变化,Ts 细胞百分率增高,Th/Ts 细胞比值下降。一盘珠汤治疗3天后总 T 细胞略升高,其他异常变化均可恢复正常,而生理盐水对照组上述各项异常值仍无明显变化。两组各项异常指标比较,除总 T 细胞百分率无显著性差异外(P>0.05),Ts 细胞百分率及 Th/Ts 细胞比值用药后各时期均有非常显著性差异(P<0.01)。表明一盘珠汤对创伤后 T 细胞亚群变化具有一定的免疫调节作用。

英文摘要:

The effects of Yipanzhu decoction (YD) on immune function in 40 patients[2 groups,YD and normal saline (NS) group]with orthopeadic trauma by taking T lymphocyte subsets as indexes were observed.The peripheral venous blood samples randomly taken from 30 healthy subjects served as control.The blood were collected within 24 hours after trauma,Then the YD and NS were respectively given to the patients in the 2 groups for 3 days,and the blood were havested 4th,7th, 14th day after trauma for the observation of T subsets.The results revealed that before administra- tion of YD the percentage of pan-T cells was reduced with an increased percentage of Ts cells and a decreased ratio between Th and Ts cells;3 days after giving the drugs in Y-D group the percentage of pant cells was slightly increased,and the changed percentage of Ts cells and the ratio of Th/ Ts cells mentioned above was recovered to normal, while in NS group all these indexes remained at abnormal range during the period we observed.The results suggested that YD could promote the recovery of abnormal T lymphocyte subsets in traumatized patients,and it possessed to some extent the function of immune regulation that was helpful to reduce the ratio of infection after trauma.

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