棉酚、GnRHa等药物对在位、异位子宫内膜细胞前列腺素含量的影响

采用放射免疫法测定正常人及子宫内膜异位症患者在位、异位子宫内膜培养细胞6-酮-PGF_1a和 TXB₂的含量,并观察醋酸棉酚、孕酮、丹那唑及 GnRHa 作用于实验细胞后前列腺素含量的变化。结果表明,患者在位、异位子宫内膜培养细胞6-酮-PGF_1a和TXB₂含量高于正常人,除 GnRHa 外,醋酸棉酚等三药使患者在位、异位子宫内膜培养细胞6-酮-PGF_1a或/和 TXB₂含量降低。提示前列腺素与子宫内膜异位症的病理生理变化有关,药物对前列腺素的直接抑制作用是抗子宫内膜异位症机制之一。

英文摘要:

In order to study a direct effect of some traditional and western medicine on the prostaglandins（PGs） of endometriosis,endometriotic cell and endometrial cell in situ were cultured in vitro.6-keto-PGFlα and thromboxane（TXB₂）were measured in the above cells using the RIA from the superfusates.These PGs changes after gossypot acetate,progesterone,danazol and gonadotrophin releasing hormone agonist（GnRHa）treatment were studied.High PGs levels were observed in endometriotic cell,and higher in endometrial cell in situ of patients than in endometrial cell of healthy persons（P<0.01）.After.treatment with drug（but not OnRHa）,the prostacyclin（PGI₂） and TXB₂ content were reduced in endometriotic cell,and the TXB₂ contents were reduced in endometrial cell in situ （P<0.01）.These results indicate that endometriotic cell and endometrial cell in situ can produce more PGI₂ and TXB₂—at least in vitro,which perhaps may provide an explanation for the puzzling clinical phenomenon of endometriosis. Gossypol acetate,progesterone and danazol inhibit PGI₂ and TXB₂ content in endometrial cell of patients with endometriosis.It is pertinentto ask whether these drugs can be used to improve endometriosis-associated infertility or dysmenorrhea as well.

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