川芎嗪治疗妊娠高血压综合征临床分析

作者	单位
钱晓华	湖北省妇幼保健院武汉 430070
黄玉兰	湖北省妇幼保健院武汉 430070
吴诗萍	湖北省妇幼保健院武汉 430070

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中文摘要:

将75例妊娠高血压综合征(妊高征)病人随机分为二组,对照组用硫酸镁20～25g/日治疗,治疗组用川芎嗪120～160mg/日治疗。结果:治疗组总有效率82.9%,明显优于对照组,P<0.01;MAP 明显下降 P<0.01;水肿和蛋白尿明显减轻,P<0.05,血液流变性改变,特别是红细胞压积显著下降,P<0.001.但胎儿 NST 阳性率和 Apgar 评分与对照组比较无显著性差异。说明川芎嗪治疗妊高征的主要机理趋扩张血管、改善肾功能和改善血液流变性。

英文摘要:

75 patients with hypertension syndrome of pregnancy (HSP) were randomly designed to 2 groups:the control group treated with magnesium sulfate (20～25g/d) and the Ligustrazine (120～ 160mg/d) group.The results of Ligustrazine group compared with the control group were as follows: (1)Mean arterial pressure was significantly decreased (P<0.01).(2)Edema and proteinuria was lowered(P<0.05).(3)The condition of theology was improved,especially,hematocrit was significant- ly decreased (P<0.001).(4)The positive rate of NST and Apgar’s score were not-different between the 2 groups.Clinical monitoring showed Ligustrazine without side effects in the group.Mechanisms of Ligustrazine in HSP were (1)dilating blood vessel;(2)improving kidney function;(3)improving microcirculatory and rheology.

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