更年新方治疗更年期综合征的临床观察

临床观察发现,更年期阴虚心火旺患者尿儿茶酚胺增高,阴虚肝火旺患者尿17-羟皮质类固醇增高,阴虚心肝火旺患者两者均增高。且阴虚火旺各组患者,反映中枢儿茶酚胺水平的去甲肾上腺素和肾上腺素的比值均高于正常。运用更年新方治疗后,在改善症状的同时,以上各项指标均有所下降,临床治疗总有效率为89.2%。分析本方作用机理,可能与降低中枢儿茶酚胺水平,从而抑制交感—肾上腺髓质和交感—肾上腺皮质系统的过度兴奋有关。

英文摘要:

It was found by the observations of clinical treatment that the three indexes of epinephrine(E), norepinephrine(NE)and dopamine(D)of urinary catecholamine(CA)increased (P<0.001,P<0.05 and P<0.001) for the climacteric patieuts who suffered from the deficiency of Yin(阴)leading to the hyperactivity of the internal heat of the heart,and the urinary 17-hydroxycorticoid (17-OHCS) increased (P<0.001) for the patients who suffered from the deficiency of Yin leading to the hyperactivity of the internal heat of the liver.Both the three indexes and urinary 17-OHCS increased for the two groups (P<0.01).However,for all the above grougs who suffered from the deficiency of Yin leading to the hyperactivity of the internal heat,the NE/E ratio was larger than the normal ratio,which stands for the level of central catecholamine.After the treatment with new Gengnian prescriptions,the clinical symptoms of the patients were improved,and in the meantime urinary CA. 17-OHCS and NE/E were decreased.The total efficiency was 89.2%.The principle of treatment with this prescription may be due to the fact that the level of central catechotamine decreased so that the excessive excitation of sympatheticus-adrenocortex system and sympatheticus-adrenocortical system was restrained.

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