| 张凤春,郑丽杰,戴洪龄,于家齐.丹参及肝素不同给药方式对肺心病患者血浆ATⅢAg、ATⅢ:A及α-M的观察[J].中国中西医结合杂志,1991,(10):589-591,579 |
| 丹参及肝素不同给药方式对肺心病患者血浆ATⅢAg、ATⅢ:A及α-M的观察 |
| Effects of Different Administration of Salvia miltiorrhiza and Heparin on ATIIIAg,ATIII:A and α2-M in Patients with Cot Pulmonal |
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| DOI： |
| 中文关键词: 丹参 肝素 肺心病 抗凝血酶Ⅲ α2-巨球蛋白 |
| 英文关键词:Salvia miltiorrhiza heparin cor pulmonal antithrombin Ⅲ α2-macroglobin |
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| 中文摘要: |
| 本研究通过采用丹参、肝素的不同给药方式治疗了102例肺心病急性发作期患者,观察其对血浆抗凝血酶Ⅲ抗原（ATⅢAg）、抗凝血酶Ⅲ活性（ATⅢ:A）及α2-巨球蛋白（α2-M）的影响。结果提示:（1）肺心病急性发作期 ATⅢ:A 极低,肝素静脉滴注可进一步消耗 ATⅢ:A。（2）肝素雾化吸入可促进 ATⅢ:A 上升。（3）丹参具有 ATⅢ的抗凝活性,丹参静脉滴注与肝素雾化吸入联合用药是治疗肺心病高凝状态的较好方法,其分别明显优于肝素静脉滴注、雾化吸入及丹参静脉滴注。 |
| 英文摘要: |
| The effects of different administration of Salvia miltiorrhiza（SM）and heparin on ATIII and α2-M in 102 patients.with cor pulmonal were studied.The results showed that（1）the level of ATIII in patients was significantly lower than that in the controls（P<0.01）.Heparin intravenous drip induced ATIII decreased;（2）the level of ATIII:A in patients with heparin vapour inhalation treat- ment was significantly higher than that with regular treatment and with heparin intravenous drip （P<0.05）and（P<0.005）;（3）SM presents ATIII-like activity,after treatment with SM,the level of ATIII:A was significantly higher than that with heparin vapour inhalation,heparin intravenous drip and regular treatment（P<0.05～0.005）,heparin may enhance the ATIII-like activity of SM;（4） the treatment combining SM intravenous.drip with heparin vapour inhalation is an efficient therapy of anticoagnlation on the patients with cor pulmonal.The level of α2-M in each group did not reveal significant change. |
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