黄芪对冠心病患者红细胞内钠含量和钠转运的影响

作者	单位
金椿	上海医科大学华山医院心内科
戴瑞鸿	上海医科大学华山医院心内科
周峰	上海医科大学华山医院心内科
鲁珊妹	上海医科大学基础医学部化学教研室
王凯羚	上海医科大学基础医学部化学教研室
陶鸿根	上海医科大学基础医学部化学教研室

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中文摘要:

本研究旨在观察黄芪注射液对冠心病患者红细胞内钠含量和钠转运的影响。67例冠心病患者随机分为黄芪治疗组和对照组。治疗组以黄芪注射液24g 溶于5%葡萄糖液250ml 内静脉滴注,每日1次,共14天;对照组静脉滴注5%葡萄糖液250ml,每日1次,共14天。结果表明,治疗组45例患者的红细胞内钠浓度下降(P<0.01),钠泵活性提高(P<0.01),而对照组无明显变化。提示黄芪具有提高红细胞钠泵活性的作用。

英文摘要:

The purpose of this study was to investigate the effect of Astragalus membranaceus(AM) on erythrocyte sodium content and sodium transport in the coronary heart disease(CHD).67 cases of CHD was randomly divided into treatment group (TG) and control group(CG),TG(45 cases)were treated with AM intravenous 24 g/d infused into 5% glucose 250ml,CG(22 cases)with 5% glucose 250ml.After a curable stage of 14 days,results showed that the erythrocyte sodium content was markedly decreased and the sodium pump activity was significantly increased (P<0.01 respectively) in TG;but no significant difference in membrane permeability to sodium was observed.There were no difference in erythrocyte sodium content and sodium transport in CG.It was suggested that AM had the effects to increase erythrocyte activity of sodium pump.

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