加味桃核承气汤治疗Ⅱ型糖尿病的临床和实验研究

作者	单位
熊曼琪	广州中医学院附属医院
梁柳文	广州中医学院附属医院
林安钟	广州中医学院附属医院
吴清和	广州中医学院附属医院
张国梁	浙江省舟山县人民医院
苗理平	广州中医学院附属医院
郑俊煦	广东省中医院
刘建奇	广州中医学院附属医院

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中文摘要:

本文报道用加味桃核承气汤治疗Ⅱ型糖尿病106例,总有效率79%,与西药优降糖组疗效相当;但降糖幅度和临床主要症状的改善方面均较优降糖组为优。动物实验表明,加味桃核承气汤能降低糖尿病及正常大鼠的空腹血糖浓度,促进β细胞分泌内源性胰岛素,抑制胰及胰外组织分泌胰高血糖素,对胰岛内分泌细胞有一定的修复功能及增加胰岛β细胞的分泌颗粒,刺激肝糖原的合成,抑制肝糖原的分解。认为加味桃核承气汤的作用机理是"益气养阴、活血化瘀、润肠通下"的协同作用。

英文摘要:

This paper reported the results of clinical observation on a treatment with Semen Persical decoction for purgation with addition (SPDPA) in type II diabetes mellitus. The effective fate of SPDPA on 106 cases of noninsulin dependent diabetes mellitus (NIDDM) was 79%. The efficiency of SPDPA was equivalent to glyburide. From the experimental study, it can be concluded that SPDPA could reduce blood sugar and relieve symptom in diabetic patients and rats. Its mechanism may be due to improving secretion of insulin, inhibiting production of glucagon, repairing insular endocrine ceil, increasing endocrine pellet of insular B cell and improving composition of hepatic glucogen. In traditional Chinese medicine theory, the mechanism of therapeutic action of SPDPA in diabetes mellitus is based on synergistic regulation of benefiting Qi(气) and nourishing Yin (阴), activating blood circulation to dissipate blood stasis and loosening the bowel to relieve constipation.

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