重症病毒性心肌炎的中西医结合治疗研究

作者	单位
陈曙霞	上海第二医科大学附属仁济医院上海 200001
常佩伦	上海第二医科大学附属仁济医院上海 200001
包世宏	上海第二医科大学附属仁济医院上海 200001
郑新娟	上海第二医科大学附属仁济医院上海 200001
梅尚文	上海第二医科大学附属仁济医院上海 200001
章隆泉	上海第二医科大学附属仁济医院上海 200001

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中文摘要:

本研究分A、B两组对33例重症病毒性心肌炎进行治疗。A组18例用肾上腺皮质激素加中药治疗;B组15例用肾上腺皮质激素加干扰素治疗。对比两组治疗结果:（1）在缓解窦房阻滞、房室传导阻滞、室性心动过速及急性泵衰竭等临床症状以及心电图的改善方面效果类同。（2）不论A组或B组在治疗后其OKT₃、OKT₄、OKT₈、OKT₄/OKT₈以及NK细胞活性均较治疗前升高,P值均<0.05或<0.01,有显著性差异,但A、B二组间无差异。说明中药治疗的效果与价格昂贵的干扰素相似,且无副作用。

英文摘要:

33 patients divided into 2 groups for treatment. Group A （18 cases） early use of adrenal cortico-steroid treatment in combination with traditional Chinese medicine, group B （15 cases） early use of adrenal cortico-steroid treatment is combination with interferon, then compared the therapeu-tic effects of these 2 groups. The results showed that, in these 2 groups, the sinus-atrial block,atrial veotricular block, ventricular tachycardia, acute pump failure as well as the EKG changes were relieved and improved to the same degree. In group A, after therapy the parameters of OKT₃ （%）was elevated from 51±15.22 to 55.23±8.53; OKT₄（%） was elevated from 30.06±11.47 to 47.32±10.87; ratio of OKT₄/OKT₈ was elevated from 1.11 to 1.53; all of their P values were<0.01. NK cell activity was elevated from 8.36±3.75 to 13.08±5.77, P value<0.05. In group B, the parame-ters of OKT₃ （%） was elevated from 50.91±8.12 to 56.75±8.29: OKT₄（%） was elevated from 32.55±6.78 to 45.13±10.85: ratio of OKT₄/OKT₈ was elevated from 1.00±0.21 to 1.37±0.16: P value <0.05, <0.05 and <0.01 respectively. NK cell activity （%） was elevated from 8.20±3.08 to 14.03±4.89, P value also<0.01. Hence, not only in group A but also in group B, after therapy, theparameters of OKT_3,4,8, OKT₄/OKT₈ and NK cell activity（%）were all improved. But there was no significant statistical difference between group A and B. It suggested that, traditional Chinese medicine therapy might be used instead of expensive interferon therapy with no side effect.

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