复方苍豆丸治疗食管癌癌前病变的临床研究

作者	单位
侯浚	河北省肿瘤研究所
阎付荣	河北省肿瘤研究所
李绍森	磁县肿瘤防治所
李中元	涉县肿瘤防治所
陈志峰	河北省肿瘤研究所

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中文摘要:

1988年我们在食管癌高发区河北省磁县和涉县8个乡中进行食管脱落细胞学拉网普查,共查出食管上皮细胞重度增生患者648例。将全部患者随机分为治疗组和对照组。治疗组服用苍豆丸,对照组服用安慰剂。2年后复查,结果:治疗组食管癌癌变率为1.5%,对照组癌变率为4.2%,两组比较差别有非常显著性意义(P<0.005);治疗组重度增生好转率79.5%,对照组好转率50.2%,两组之间比较差别也有非常显著性意义(P<0.01)。说明苍豆丸有一定防癌作用。

英文摘要:

In this report, 648 cases of marked epithelium hyperplasia diagnosed with esophageal exfolia-tive cytology wer studied clinically in the high incidence areas (Cixian and Shexian) of esophagealcancer. All these cases were randomly divided into the treated group and the control group. For twoyears, the former group had been given Cang Dou Pill (苍豆丸) and the latter the placebo. The resultsreexamined by the cyto-smears showed that the incidence of the esophageal cancer in therapeuticand control group were 1.5% and 4.2% respectively. A significant difference existed between thetwo groups (P<0.005). And the reverse rate of marked hyperplasia in the treated and control groupwere 79.5% and 50.2% respectively. There was significant difference between the two groups (P<0.01). These results showed that Cang Dou Pill, to some extent, has anti-cancer activity.

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