赵泽贞,黄民提,李琦,秦愉荣.茶叶抑制六种抗肿瘤药物诱变性的实验研究[J].中国中西医结合杂志,1992,(10):620-621,582 |
茶叶抑制六种抗肿瘤药物诱变性的实验研究 |
Experimental Study on Tea in Inhibiting Mutational Specificity of 6 Antineoplastic Drugs |
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DOI: |
中文关键词: 茶叶 抗肿瘤药物 SOS反应 抗诱变 |
英文关键词:tea antineoplastic drugs SOS test anti-mutational |
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中文摘要: |
本文报告依据超氧化物歧化酶(SOS)反应原理,采用诱变及抗诱变同步试验方法,检测了茶叶的诱变性和对六种抗肿瘤药物诱变性的抑制作用。结果表明,茶叶无诱变毒性并有抗诱变作用。茶叶对丝裂霉素C(MMC)、平阳霉素氟尿嘧啶顺氨氯铂、阿糖胞苷及盐酸氮芥六种治疗肿瘤药物的诱变毒性均有抑制作用。为进一步研究茶叶的抗癌作用及临床应用提供了参考依据。 |
英文摘要: |
According to the principles of SOS response, the authors tested the mutational specificity of teaand its inhibitory effects to the mutational specificity of 6 antineoplastic drugs by using the methodof motational and anti-mutational synchronous test. The results revealed that the tea had nomutational toxicity but anti-mutation effect. It also had the inhibitory effect on mutational toxicityof 6 antineoplastic drugs, including Mitomycin C, Bleomycin, Fluorouracil, Cis-diaminodichoroplatinum, Arabinosylcytosin and Mustargen. These results have provided referentialbasis for further study on anti-cancer effect and clinical use of tea. |
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