脉络通治疗家兔原位免疫复合物型肾小球肾炎的实验研究

作者	单位
汪琼玲	同济医科大学附属同济医院内科
孙世澜	同济医科大学附属同济医院内科
刘晓城	同济医科大学附属同济医院内科
黄寿珍	同济医科大学病理教研室

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中文摘要:

应用阳离子化牛血清白蛋白复制家兔原位免疫复合物型肾小球肾炎,以活血化瘀中药脉络通治疗,结果治疗组尿蛋白较对照组明显减少,P<0.01;其组织病变较对照组减轻,肾小球毛细血管内未见微血栓,未见红细胞、血小板聚集及白细胞嵌塞,系膜细胞增生及中性白细胞浸润明显减少,P<0.01;肾小球无明显纤维化。提示脉络通的治疗作用可能与其抑制血小板聚集、调节血栓素A₂/前列环素系统平衡失调、促进免疫复合物吸收以及抑制肾小球纤维化有关。

英文摘要:

Applying c-BSA to duplicate immune complex in situ type glomerulonephitis in rabbits andtreating it with Blood Circulation Promoting and Stasis-Removing Drugs Mai-Luo-Tong, the results showed that proteinuria in the treated group was decreaseed significantly, as compared to thecontrol group (P<0.01). Under light and electron microscope, although glomerular basementmembrane was irregularly thickened and subepithelial dense clectron deposits were found in bothgroups, but histopathologic damage in the treated group less than that of control one. In the treatedgroup micro-thrombus, erythrocytes and platelets aggregation, leukocytes impaction were not seenwithin glomerular capillary. Also in the treated group masangial cell proliferation and granulocyteinfiltration were decreased significantly(P<0.01) and there was no apparent glomerular fibrosis informer group.

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