| 周建燮,刘锐,杨世兴,乔成林,周清发.益肾降脂汤对慢性肾功能衰竭的实验研究[J].中国中西医结合杂志,1993,(1):36-38,6 |
| 益肾降脂汤对慢性肾功能衰竭的实验研究 |
| Experimental Study on Kidney Invigorating and Lipid Reducing Decoction —Yishen Jiangzhi Tang in Treating Chronic Renal Failure |
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| DOI： |
| 中文关键词: 益肾降脂汤 慢性肾功能衰竭 腺嘌呤 代偿 异物肉芽肿 |
| 英文关键词:Kidney Invigorating and Lipid Reducing Decoction chronic renal failure adenine foreign body granuloma |
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| 中文摘要: |
| 用腺嘌呤灌胃造成大白鼠慢性肾功能衰竭动物模型,然后观察益肾降脂汤的疗效。结果治疗组动物精神和体重恢复良好,多尿情况好转,尿蛋白减少,血清尿素氮、肌酐下降,均优于恢复组。在肾脏病理检查方面,肾脏实质性损害虽未逆转,但代偿情况良好,未受损的肾单位代偿性肥大,病损部位以多核巨细胞和异物肉芽时反应为主,间质淋巴细胞浸润,纤维化不明显。而恢复组病损严重、纤维化,说明益肾降脂汤可增强机体代偿适应能力,提高机体免疫力,促进蛋白合成,改善肾功能。对于从内科保守疗法看手治疗慢性肾功能衰竭是一有益的探索。 |
| 英文摘要: |
| In explorating the effect of treatment of supporting the body resistance on chronic renal failure,a chronic renal failure model of rat was created by gastroperfusion of adenine and evaluation wasmade on the therapeutic effect of Kidney Invigorating and Lipid Reducing Decoction (KILRD). Themental state and body weight of the treated group have recovered well with polyuria and proteinureaimproving, BUN and Creatinine decreasing, Which appeared to be superior to the natutally recoverdgroup. Renal pathological examination showed that: although the renal parenchymal damage wasnot reversed but its compensation was satisfactory with compensatory hypertrophy appearing inunaffected nephron. The dominant reaction in the affected area was polynucleomacrocytosis, foreignbody granulamatosis, and ioterstitial lymphocytic infiltration, the fibrosis was inevident, while theabove-mentioned condition in the naturally recovered group was relatively more serious, withfibrosis being observed. It was indicated that KILRD could increase the compensatoty capacity andimmunity, promote protein synthetization and improve renal function. The study on KILRD Provedto be a significant conservative medical treatment for chronic renal failure. |
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