异搏定结合肾病基本方对肾病综合征Ⅱ型血液流学指标的影响

本文将24例原发性肾病综合征Ⅱ型的患者随机分为异搏定治疗组和异搏定结合患病基本方组。测定了两组患者治疗前及治疗后4周的血液流变学指标。结果显示异搏定组治疗后高粘血症明显改善(P<0.05),而异搏定结合基本方组较单用异搏定组效果更佳。提示了钙通道阻滞剂可以通过抑制血小板聚集而起到抗凝作用。而基本方中的桃仁、红花等味中药具有抑制血小板聚集、抗凝及疏通微循环作用,与异搏定合用对改善肾病综合征高凝状态起到更好效果。

英文摘要:

24 cases of type Ⅱ nephrotic syndrome were studied and divided randomly into two groups.Group A: 12 cases treated with verapamil; Group B: 12 cases treated with verapamil plus RenalDisease Basic-Prescription (RDBP). Hemorheology indexes were measured in the two groups beforeand 4 weeks after the treatment. The results showed hyperviscosity was obviously improved in groupA after verapamil administration (P<0.05), but the improvement in group B was much moresignificant than that in group A. The results mentioned above indicate that calcium channed blockerhas an anticoagulant effect with inhibiting platelet aggregation, and Peach kernel, Safflower, etc ofRDBP played a role in prohibiting platelets aggregation, anticoagulation and promoting microcir-culation. However the combination of the two methods has better effect in improving the hyper-coagulable state of nephrotic syndrome

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