参麦注射液对胸腹呼吸运动影响

作者	单位
王为	同济医科大学附属同济医院呼吸病研究室
牛汝楫	湖北省沙市第二医院呼吸内科
孙建平	湖北省沙市第二医院呼吸内科

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中文摘要:

30例慢阻肺患者,因隔肌疲劳电阻抗呼吸图显示胸腹反常矛盾呼吸运动,分为A、B两组,分别先后静脉注射参麦注射液和10%葡萄糖注射液,观察其电阻抗呼吸图所示胸壁腹壁运动曲线的变化。使用参麦注射液后有26例在2h内转为同步呼吸运动,有效率显著高于葡萄糖治疗组(P<0.01)。本结果显示参麦液对疲劳膈肌有正性肌力作用。

英文摘要:

Diaphragmatic muscle fatigue (DMF) has long been recognized as causing and developingrespiratory failure in patients with chronic obstructive pulmonary disease (COPD). Paradoxicalmotion of thoraco-abdomen is one of asychronous breathing pattern, which is clinical sign of DMF.Thoracoabdominal motion curves were recorded with impedance respirograph (IRG). Indexes, α andM on IRG correlated well to the degrees of asynchronous breathing movement. 30 patients withCOPD, their IRG showed patadoxical motion of thoraco-abdomen were divided randomly inio twogroups of 15 cases. Group A was treated intravenously with Sheng Mai injection at first and withglucose later. Among patients of group B, preceding Sheng Mai injection was glucose. IRG wererecorded before and after treatment. Results showed that the IRG of 26 patients treated with ShengMai injection changed from paradoxical pattern to sychronous one. The difference of the indexes αand M before and after treatment of Sheng Mai injection was statistically significant (P<0.001).Only one patient treated with glucose changed from paradoxical to sychronous pattern. Thedifference of the indexes between treated and non treated with glucose was not statistically signifi-cant (P<0.05). This study suggest that Sheng Mai injection has a positive inotropic effect on fatigueddiaphragmatic muscle.

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