保元汤对慢性肾炎患者血清脂质过氧化物水平和维生素E含量的影响

作者	单位
金一平	湖南医科大学第二附属医院长沙410011
杨锡兰	湖南医科大学第二附属医院长沙410011
吴轰	湖南医科大学第二附属医院长沙410011
宋其昌	湖南医科大学第二附属医院长沙410011
杨济果	湖南医科大学第二附属医院长沙410011

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中文摘要:

作者用保元汤治疗慢性肾炎18例,观察患者血清脂质过氧化物(LPO)水平和维生素E(VE)含量的变化,并作疗效分析。结果显示该方能降低尿蛋白、血肌酐,提高血清蛋白及血红蛋白含量,总有效率为83.3%。保元汤治疗前患者LPO为4.89±1.85μmol/L,高于对照组3.36±0.59μmol/L(P<0.001);VE含量为4.27±1.84μg/ml,低于对照组7.03±0.69μg/ml(P<0.05)。治疗后患者血清LPO为3.76±1.49μmol/L,低于治疗前(P<0.05);血清VE为5.33±2.45μg/ml,与治疗前比较差异无显著性意义。患者LPO与VE含量呈负相关性。提示该方具有抑制脂质过氧化反应的作用。

英文摘要:

Serum lipid peroxide (LPO) and vitamin E (VE) were determined in 18 patients with chronic glomerulonephritis (CGN) before and after treatment with Baoyuantang (BYT). It was found that before treatment the level of serum LPO (4.89±1.85μmol/L) was higher, while the content of serum VE (4.27±1.84μg/ml)was lower than those of normal controls (3.36±0.59μmol/L, P<0.001; 7.03± 0.69μg /ml, P<.05). After treatment with BYT, the level of LPO lowered to 3.76±1.49μmol/L, P <0.05, as compared with the value before treatment, while the content of VE was increased to 5.33±2.45μg/ml, but without statistical significance. A negative correlation was found between LPO level and VE content both before and after treatment (r=-0.495,P<0.05; r=-0.522,P<0.05). The results indicated chronic deficiency of VE in association with an increase in the level of LPO in the kidney in CGN patients and inhibition of LPO by BYT. After treatment complete remission was observed in 5 cases, basic remission in 3, and partial remission in 7.

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