五叶参抗血栓形成作用的研究

作者	单位
谭获	广州医学院第二附属医院广州 510260
刘泽霖	广州医学院第二附属医院广州 510260
刘敏涓	广州医学院第二附属医院广州 510260
冯莹	广州医学院第二附属医院广州 510260
关东文	广州医学院第二附属医院广州 510260
张微	广州医学院第二附属医院广州 510260

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中文摘要:

用人血进行体外实验研究证实,五叶参水煮制备液能明显抑制APD、复合诱聚剂诱导的血小板1min、5min、最大聚集率,并促进解聚发生(P均<0.05);该药还对体外血栓形成具有显著的抑制作用(P<0.05);五叶参水煮液与PPP混合后,尚能抑制多种凝血因子活性,使KPTT、PT、TT、AT、RVV-RT、RVV-CT等凝血试验时间延长(P均<0.05);此外,五叶参有加速红细胞电泳速度的作用。上述结果表明,五叶参是一种具有抑制血小板功能、凝血功能及红细胞聚集性等多个环节的抗血栓形成药物,值得进一步研究探讨。

英文摘要:

Human blood samples were investigated in vitro to observe the antithrombotic effect of waterextract of Gynostemma pentaphyllum (GP). The results showed that GP could inhibit significantly theplatelet aggregation induced by ADP and compound agonists (P<0.05), accelerate obviously thedisaggregtion (P<0.05) and inhibit effectively the experimental thrombosis (P<0.05). The delayedeffects of GP on KPTT, PT, TT, AT, RVV-RT, RVV-CT suggested that this drug could decreasethe activity of multiple coagulation factors. And it showed that GP could accelerate the erythrocyteelectrophoresis rate. This study revealed that GP is an antithrombotic agent affecting the links ofthrombotic chain which is worthwhile to be studied further.

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