羟基喜树碱、斑蝥素联合顺氯氨铂经肝动脉栓塞治疗原发性肝癌48例

作者	单位
于志坚	南通医学院附属医院消化研究室
孟宪镛	南通医学院附属医院消化研究室
徐克成	广东深圳蛇口联合医院
葛政举	南通医学院附属医院消化研究室

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中文摘要:

我们采用羟基喜树碱、斑蝥素联合顺氯氨铂,与碘化油混合经肝动脉行栓塞灌注,合并大剂量干扰素、白细胞介素等过继免疫方法,治疗手术未能切除的中、晚期肝癌48例。成功地消除了这二种中药制剂全身应用所致血尿、尿痛等不良反应,并取得优于顺氯氨铂与阿霉素、丝裂霉素等常规化学药物栓塞治疗的良好效果。两组病例部分缓解率分别为54.2%、32.1%(P<0.01)。

英文摘要:

Transcatheter arterial embolization (TAE) using hydroxycamptothecin, cantharidin and cis-platin which were mixed thoroughly with lipiodol, combined with large doses interferon and interleu-kin-2 as adoptive immunotherapy were carried out in the treatment of 48 patients with unresectableadvanced stage primary hepatoma, evaluation of therapeutic effect showed that partial remissionrate was 54.2%, significantly higher than that of embolization group using chemotherapeutic agentsalone (cisplatin, adriamycin and mitomycin), the partial remission rate was 32.1% (P<0.01). The sideeffects of camptothecine and cantharidin including hematuria, urodynia were also successfullyeliminated.

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