丹酚酸B-镁盐抗大鼠D-半乳糖胺肝损伤的作用

作者	单位
刘平	上海市中医药研究院肝硬化研究室
森泽成司	日本大阪市立大学医学部生化学教室
溝口靖紘	日本大阪市立大学医学部生化学教室

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中文摘要:

应用丹参水溶性活性成分——丹酚酸B-镁盐抗大鼠D-半乳糖胺肝损伤,可显著降低血清丙氨酸氨基转移酶（ALT）、门冬氨酸氨基转移酶（AST）活性,减轻肝细胞坏死。提高肝非实质细胞花生四烯酸代谢产物6-酮基-前列腺素F_1α(6-keto-PGF_1α)、前列腺素D₂（PGD₂）及前列腺素总的生成量。表明丹酚酸B-镁盐可能是丹参抗肝损伤的主要成分,其提高肝非实质细胞前列腺素（PGs）总的生成量可能是其抗肝损伤的机制之一。

英文摘要:

To investigate the effective ingredients of Salvia miltiorrhizae on anti-liver injury, the watersoluble component of the above drug, magnesium lithosperamate B, was used to conduct theexperimental treatment of acute liver injury by D-galactosamine （10 mg/kg body weight, orally）.The results showed that the component could obviously attenuate the necrosis of liver tissues, lowerthe activities of serum alanine amino transferase （ALT） and asparate amino transferase （AST）, P<0.05. Compared with those of the normal rats, the levels of the products of cyclo-oxygenase（6-keto-prostaglandin F₁α, prostaglandin D₂ and total prostaglandins） in the metabolism of ara-chidonic acid in non-parenchymal cells of acote liver-injured rats were markedly decreased （P<0.05）. These data revealed that magnesium lithosperamate B might be one of the main componentsof Salvia miltiorrhizae in anti-liver injury, while increasing the levels of total prostaglandins in livernon-parenchymal cells was perhaps one of the mechanisms of anti-liver injury.

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