| 汪大金,毛焕元,雷明,方玉珍,涂源淑.新的植物性钙拮抗剂颅通定治疗心房颤动的临床研究[J].中国中西医结合杂志,1993,(8):455-457,451 |
| 新的植物性钙拮抗剂颅通定治疗心房颤动的临床研究 |
| Clinical Study of Rotundium in Treating Atrial Fibrillation |
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| DOI： |
| 中文关键词: 颅通定 钙拮抗剂 延胡索 心房颤动 动态心电监测 |
| 英文关键词:L-tetrahydropalmatine Rotundium atrial fibrillation ambulatory electrocardiographic monitoring calcium antagonist |
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| 中文摘要: |
| 首次应用中药延胡索的生物碱——左旋四氢巴马汀(即颅通定)口服治疗心房颤动(房颤),以动态心电图或心电遥测技术评定疗效,结果显示:对阵发性房颤有效率81.8%,持续性房颤有效率43.0%,其抗房颤机理与该药延长心房和房室结有效不应期有关。分析了影响药物疗效的因素和药物对血压、心率的作用。该药无严重副作用。表明颅通定是一种治疗房颤安全有效的药物。 |
| 英文摘要: |
| L-tetrahydropalmatine (Rotundium) is an alkaloid of Corydalis turtschaninovii. Some animalexperiments had demonstrated that Rotundium had a good antiarrhythmic effect in blocking thecalcium channel and that it was a class Ⅳ antiarrhythmic agent, similar to that of Bepridil inliteratures. This is a clinical report of Rotundium (oral given) on an atrial fibrillation (AF) patients.The therapeutical results were evaluated by 24 hours ambulatory electrocardiographic monitoringand ECG. The results showed that the effective rate of Rotundium on paroxysmal atrial fibrillationand sustained atrial fibrillation of 45 mm (left atrium diameter) or more was 30%, while LAD of lessthan 45mm was 80% (P<0.01). Among 8 cases duration of AF were 6 months or more, 3 cases wereeffective, the effective rate 37.5%, while among 10 cases’ duration of AF were less than 3 weeks, 3cases were converted to sinus rhythm, 5 cases were effective. There was a significant differencebetween two groups. Age and sex exerted no effect on efficacy. During taking Rotundium, bloodpressure had no apparent changes and no severe side effects were found. The results showed thatRotundium is an effective, safe new drug to treat AF, especially in paroxysmal atrial fibrillation.The antiarrhythmic mechanism of Rotundium might be related to its prolonging of the effectiverefractory period of atrial and atrioventricular node. |
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