藏药浴对类风湿性关节炎的免疫调整作用

作者	单位
赵淑兰	青海医学院微生物免疫教研室
耿排力	青海医学院微生物免疫教研室
陆东明	青海医学院微生物免疫教研室
刘彦萍	青海医学院微生物免疫教研室
朱一木	青海省藏医院
桑杰	青海省藏医院
李占财	青海医学院附属医院检验科
孔庆海	青海医学院附属医院检验科
黄大海	青海医学院附属医院检验科
张淑珍	青海医学院附属医院检验科

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中文摘要:

本研究探讨了藏药浴对类风湿性关节炎（RA）的免疫调整作用。结果表明,经藏药浴治疗后类风湿因子（RF）转阴或下降率达70.6%;IgG、IgM、IgA水平显著降低;³H-TdR掺入淋巴细胞转化刺激指数下降;CD₈⁺细胞数回升;CD₄⁺/CD₈⁺比值下降。实验证明,藏药浴可通过纠正CD₄⁺与CD₈⁺细胞比例失衡而使RA患者免疫功能紊乱得以调整。

英文摘要:

The changes of the immune function of rheumatoid arthritis before and after the Tibetan medicated-bath was observed. It showed a higher level of the rheumatoid factor （RF） titre, immunog-lobulin （Ig） G M, A and CD4 cells, but the CD8 cells was obviously lower before the treatment.Clinical data indicated that the medicated-bath had significant effective rate. In order to elucidatethe mechanism of the medicated-bath upon rheumatoid arthritis the RF titre, lg level, complementC₃, 3H-TdR incorporated with lymphocytes transformation and CD3, CD4, CD8 cell level wereassayed. Results showed that RF titre decreased after the bath and the negative transforming ratereached 70.6%, lg level obviously dropped as well as the number of CD4 cells while CD8 cell levelillereased. The transforming stimulation index of lymphocyte cells obviollsly decreased. All of theabove mentioned showed that there was a higher concentration of the enhancing factor ofinterleukin-2 （IL2-EF） involved in lymphocyte culture of rheumatoid arthritis patients. They sug-gested that the Tibetan medicated-ba（?）h had an immunomodulating effect on rheumatoid arthritispatients through increasing the level of CD8 cells and reducing CD4 cells.

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