赵铁华,粟锦迁.生脉散加黄芪对LAK细胞抗肿瘤活性的正向调节作用[J].中国中西医结合杂志,1993,(8):471-472,453 |
生脉散加黄芪对LAK细胞抗肿瘤活性的正向调节作用 |
Positive Modulating Action of Shengmaisan with Astragalus Membranaceus on Anti-Tumor Activity of LAK Cells |
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DOI: |
中文关键词: 生脉散 黄芪 LAK细胞 细胞毒 |
英文关键词:Shengmaisan Astragalus membranaceus LAK cells cytotoxicity |
基金项目:国家自然科学基金;河北省卫生厅资助项目 |
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中文摘要: |
本文用~3H释放方法检测了生脉散加黄芪对LAK细胞活性的影响。43例LAK细胞分别对8例不同型别患者的新鲜急性白血病细胞表现了明显的杀伤活性。以最适浓度(100μg/ml)生脉散加黄芪制剂协同IL-2诱生LAK细胞,其活性明显增强。最适浓度(10μg/ml)的人参总皂甙制剂作用稍强于生脉散加黄芪制剂。 |
英文摘要: |
Enhancing the anti-tumor activity of LAK cells is one of problems which are expected to besolved in tumor clinic at present. The effects of Shengmaisan with Astragalus membranaceus(SMAM) on anti-tumor activity of LAK cells with the ~3H release assay were studied. The LAK cellstaken from 43 persons showed obvious killing activity to acute leukemia cells from 8 patients indifferent types. The results showed that the activity of LAK cells could be enhanced markedly by thesynergic action of SMAM in proper concentration (100 υg/ml) with IL-2. The effect of ginsenosidewith appropriate concentration (10υg/ml) was slightly better than that of SMAM The treatmentfor malignant tumor using SMAM assisting LAK cells could replace the application of some cellfactors which were expensive and toxic at present. |
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