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赵铁华,粟锦迁.生脉散加黄芪对LAK细胞抗肿瘤活性的正向调节作用[J].中国中西医结合杂志,1993,(8):471-472,453
生脉散加黄芪对LAK细胞抗肿瘤活性的正向调节作用
Positive Modulating Action of Shengmaisan with Astragalus Membranaceus on Anti-Tumor Activity of LAK Cells
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DOI:
中文关键词:  生脉散  黄芪  LAK细胞  细胞毒
英文关键词:Shengmaisan  Astragalus membranaceus  LAK cells  cytotoxicity
基金项目:国家自然科学基金;河北省卫生厅资助项目
作者单位
赵铁华 承德医学院 河北 067000 
粟锦迁 承德医学院 河北 067000 
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中文摘要:
      本文用~3H释放方法检测了生脉散加黄芪对LAK细胞活性的影响。43例LAK细胞分别对8例不同型别患者的新鲜急性白血病细胞表现了明显的杀伤活性。以最适浓度(100μg/ml)生脉散加黄芪制剂协同IL-2诱生LAK细胞,其活性明显增强。最适浓度(10μg/ml)的人参总皂甙制剂作用稍强于生脉散加黄芪制剂。
英文摘要:
      Enhancing the anti-tumor activity of LAK cells is one of problems which are expected to besolved in tumor clinic at present. The effects of Shengmaisan with Astragalus membranaceus(SMAM) on anti-tumor activity of LAK cells with the ~3H release assay were studied. The LAK cellstaken from 43 persons showed obvious killing activity to acute leukemia cells from 8 patients indifferent types. The results showed that the activity of LAK cells could be enhanced markedly by thesynergic action of SMAM in proper concentration (100 υg/ml) with IL-2. The effect of ginsenosidewith appropriate concentration (10υg/ml) was slightly better than that of SMAM The treatmentfor malignant tumor using SMAM assisting LAK cells could replace the application of some cellfactors which were expensive and toxic at present.
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