| 郑智华,叶任高,李幼姬,黄小平,姜傥,何惠娟.全蝎注射液对大鼠原位性肾炎病理变化及血清IL-1的影响[J].中国中西医结合杂志,1993,(8):481-482,454 |
| 全蝎注射液对大鼠原位性肾炎病理变化及血清IL-1的影响 |
| Effects of Scorpion Injection on Interleukin 1 and Pathology in Experimental Glomerulonephritis in Situ |
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| DOI： |
| 中文关键词: 全蝎注射液 白细胞介素1 原位性肾炎 |
| 英文关键词:experimental glomerulonephritis scorpion injection interleukin 1 |
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| 中文摘要: |
| 本实验在大鼠C-BSA原位肾炎模型基础上,用全蝎注射液(1.0g/kg)每日1次腹腔注射,3周后杀检。取肾皮质作病理检查,用胸腺细胞增殖法检测血清白细胞介素1(IL-1)。结果发现:全蝎治疗组的尿蛋白含量比模型组明显减少(P<0.05),血清IL-1活性比模型组显著下降(P<0.01),光镜及电镜下病理变化也有所缓解。结果提示:全蝎注射液可能对大鼠C-BSA原位肾炎血清IL-1有抑制作用,并能缓解其病理改变过程。 |
| 英文摘要: |
| The model of experimental glomerulonephritis in situ in rats was established by administrationof C-BSA. 24 male Wistar rats were randomly assigned to three groups: C-BSA, control and C-BSA+scorpion (scorpion injection, ip, 1.0g/kg, once/day). At the end of 4th week, the bioactivityof serum IL-1 was assayed by thymocyte proliferation method and the renal pathology was checkedup. Urine sample was collected for 24 hour once/week for protein determination. Result: Quantityof proteinuria in scorpion group was reduced significantly in comparing with C-BSA group. Level ofIL-1 was significantly lower in scorpion group than that in C-BSA group. Injury of renal tissue alsowas mild in the treated group. These results suggested that scorpion injection could suppress theactivities of IL-1 and ameliorate the pathological injury in this experimental glomerulonephritis insitu. |
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