大鼠肾囊丹参肾内转运动态的研究

作者	单位
田松	北京医科大学人民医院肾内科北京 100044
高沪滨	北京医科大学人民医院肾内科北京 100044
陶放	北京医科大学人民医院肾内科北京 100044
于仲元	北京医科大学人民医院肾内科北京 100044

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中文摘要:

应用高效波相色谱技术检测了大鼠肾囊注射丹参后不同时间肾脏组织和血液中丹参的浓度。结果显示肾脏组织中丹参浓度明显高于血中丹参浓度,24h达高峰,至48h仍维持在较高水平,且不依赖于血中丹参浓度变化。表明肾囊中丹参可被动转运至肾脏,形成肾脏高浓度区。以此可作为应用肾囊药物注射治疗多种肾脏疾病的基础。

英文摘要:

The concentration of Salvia miltiorrhizae (SM) was detected at different time after renalintracapsular injection in S. D rats. It showed that SM concentration was higher in kidney than inplasma (P< 0.05). SM concentration in kidney increased gradually, it reached the peak at 24 hour andstill remained in higher level at 48 hour. The SM injected in renal capsule could be passivelytransported to renal tissue and maintained at a high level. This result demonstrated that renal intracapsular injection could be applied as an important therapeutical method for different renaldisease.

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