硝酸甘油与丹参对心脏病患者血液动力学的影响

本文报告２０例心功能均在正常范围的心脏病患者，用Ｓｗａｎ－Ｇａｎｚ导管，对比测定了舌下含硝酸甘油０．３ｍｇ和静脉注射复方丹参注射液４ｍｌ之后，其即刻及１５、３０、４５ｍｉｎ的肺毛细血管嵌楔压（ＰＣＷ）、肺动脉平均压（ＭＰＡＰ）、心脏排血量（ＣＯ）、心排血指数（ＣＩ）、体表平均动脉压（ＳＭＰ）及心率（ＨＲ）的血液动力学变化。发现两种药物都有扩张血管、降低左室充盈压和增加心排血量的作用；但作用出现的时间及持续时间不同，特别是ＣＯ、ＣＩ的增加，丹参明显优于硝酸甘油，作用较持久，值得临床选用。

英文摘要:

This report investigated the hemodynamic changes of both nitroglycerin and Salvia miltiorrhiza(Co.)concerning pulmonary capillary-wedge(PCW),mean pulmonary artery pressure (MPAP),cardiac output(CO),cardiac index(CI),systemic mean pressure(SMP),and heart rate (HR).In 20 patients with heart diseases of normal cardiac function,niltroglycerin were compared with Salvia miltiorrhiza(Co.)using Swan-Ganz Catheter,which were self-compared.Result:(1)Both drugs had the similar vaso-dilating effects,reduced the filling pressure of left ventricle and increased the cardiac output but different in the time of appearance and duration, particularly concerning CO and CI.(2)The effect of Salvia miltiorrhiza(Co.)was markedly superior to the nitroglycerin.The action of former was more persistant and the improvement of cardiac function was better than that of latter.

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