| 张瑶珍,唐锦治,张玉金,徐慧珍.穿心莲提取物抗血小板聚集与释放作用及其机理的研究[J].中国中西医结合杂志,1994,(1):28-30,34,5 |
| 穿心莲提取物抗血小板聚集与释放作用及其机理的研究 |
| Study of Andrographis Paniculata Extracts on Antiplatelet Aggregation and Release Reaction and its Mechanism |
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| DOI： |
| 中文关键词: 穿心莲 血小板聚集 血小板释放 5－羟色胺 |
| 英文关键词:Andrographis paniculata platelet aggregation platelet release serotonin |
| 基金项目:卫生部资助 |
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| 全文下载次数: 1119 |
| 中文摘要: |
| 本研究对６３例心、脑血管疾病患者进行了服药后３ｈ及（或）１周的临床观察，发现穿心莲（ＡＰＮ）对１及５ｍｉｎ血小板聚集率均有明显抑制作用（Ｐ＜０．００１），且随用药时间延长（１周后）疗效更显著。通过２０名志愿者服药前后血浆及血小板５－羟色胺（５－ＨＴ）测定证明ＡＰＮ能显著抑制血小板释放５－ＨＴ（Ｐ＜０．０１）。透射电镜观察到无论体外加药还是服药后ＡＰＮ均能明显抑制ＡＤＰ诱聚所致的血小板管导系统扩张及颗粒释放。其抗血小板聚集作用可能与激活血小板膜系统的腺苷环化酶，提高血小板内ｃＡＭＰ有关。 |
| 英文摘要: |
| patients of cardiac and cerebral vascular diseases were observed at 3 hours and/or one week after taking Andrographis paniculata(AP)extracts.Results showed that both 1 min.and 5 min.platelet aggregation induced by ADP were significantly inhibited(P<0.001),33 cases of them were observed for one week.The aggregation rate was even significantly lower than that of 3 hours.Serotonin(5-HT)release reaction from platelet was observed in 20 volunteers taking AP.Result showed 5-HT released from platelet decreased(P<0.01),but plasma 5-HT level remained unchanged.The ultrastructural observation showed that AP could inhibit the releasing of dense and αagranules from platelet and dilating of canalicular,system.It suggested that a raise of platelet cAMP level might be the mechanism of antiplatelet effect of AP. |
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