| 梁晓春,郭赛珊,王香定,张孟仁,徐慧媛,陈玉碧,张延华,史泽,张宏,孙仁宇.降脂中药片降脂及抗脂质过氧化损伤的临床研究及机制探讨[J].中国中西医结合杂志,1994,(3):139-141,131 |
| 降脂中药片降脂及抗脂质过氧化损伤的临床研究及机制探讨 |
| Effect of Jiangzhi Zhongyao Pian(降脂中药片)on Serum Lipid and Antioxidation of Hperlipemic Patients |
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| DOI： |
| 中文关键词: 降脂中药片 高脂血症 抗氧化作用 |
| 英文关键词:Jiangzhi Zhongyao Pian hyperlipemia antioxidation |
| 基金项目:中国医学科学院青年科学基金 |
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| 中文摘要: |
| 采用随机分组双盲给药方法观察了降脂中药片的降脂疗效及对高脂血症患者胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）、动脉硬化指数（ＡＩ）、超氧化物歧化酶（ＳＯＤ）、血清丙二醛（ＭＤＡ）的影响。结果，该药的总有效率为ＴＣ６８．８％，ＴＧ８３．９％：治疗后ＴＣ、ＴＧ、ＡＩ、ＭＤＡ下降，ＨＤＬ－Ｃ升高，与对照组比较Ｐ＜０．０５～０．０１。提示该药可能具有调节脂代谢和清除自由基的作用。 |
| 英文摘要: |
| cases of hyperlipemic patients were divided into 2 groups,31 treated with Chinese herbal medicine Jiangzhi Zhongyao Pian(JZZYP)and the control group(31 cases)treated with placebo.Serum lipid, RBC-superoxide dismutase(RBC-SOD),and MDA were observed before and after 2 months treatment.Result showed that total cholesterol(TC),triglyceride(TG),atherogenic index(AI)and malondialdehyde(MDA) of test group were apparently dropped and high density lipidcholesterol(HDL-C),RBC-SOD activity obviously elevated after treatment,the difference between two groups was significant(P<0.05-0.001).The total effective rate of JZZYP on TC was 68.8%,that on TG was 86.7%.The results suggested that JZZYP has the effect of serum lipid regulation,antioxidase activity elevation and lipid peroxide inhibition.JZZYP had no side effect. |
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