冬虫夏草对老年人氨基糖甙肾毒性损伤的保护作用

本研究观察了冬虫夏草对老年人氨基糖甙（ＡＧ）类肾毒性的影响。随机将２１例患者分为冬虫夏草治疗组和对照组。两组同时用丁胺卡那霉素０．４ｇ／ｄ，连续６天。虫草组用冬虫夏草口服，连续７天。动态观察了尿ＮＡＧ酶和β２－微球蛋白（β２－ｍ）变化，治疗后虫草组与对照组尿ＮＡＧ酶分别为２３．５１±１０．８４ｍｕ／ｍｇ·Ｃｒ、４５．４２±２６．９７ｍｕ／ｍｇ·Ｃｒ，Ｐ＜０．０５。虫草组治疗后尿β２－ｍ＞１．０ｍｇ／２４ｈ者１例（１０％）与用药１天时６例（６０％）比较，Ｐ＜０．０５。对照组治疗后与用药１天时尿β２－ｍ比较，无统计学意义。结果证明虫草组肾毒性损伤要轻于对照组，提示冬虫夏草对老年人ＡＧ肾毒性损伤有良好的保护作用。

英文摘要:

The protective effect on aminoglycoside nephrotoxicity by Cordyceps sinensis in the old patient was observed.21 old patients were randomly divided into two groups.Each group received amikacin sulfate for 6 days.In addition,group A was administered Cordyceps sinensis for 7 days and group B was given placebo.The results revealed that group A developed less prominent nephrotoxicity compared with group B as evidenced by less urinary nephro-aminoglycosidase (NAGase) and β-microglobulin in group A than those in Group B.These results suggested that Cordyceps sinensis exerted a protective effect on aminoglycoside nephrotoxicity in the old patients.

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