何忠效,危巍,白坚石,吴志奎.抗衰老药物对大鼠肝DNA甲基化酶活力的影响[J].中国中西医结合杂志,1994,(6):354-356,325,326 |
抗衰老药物对大鼠肝DNA甲基化酶活力的影响 |
Effect of Anti-aging Drug on Activity of DNA Methylase in Rat Liver |
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DOI: |
中文关键词: 神方补肾生血药 DNA甲基化酶 抗衰老 |
英文关键词:Bushen Shengxue drug DNA methylase Chromatography |
基金项目:国家自然科学基金 |
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中文摘要: |
用神方补肾生血药处理Wistar大鼠,发现有明显的抗衰老作用。用3H-甲基掺入法测定了鼠肝DNA甲基化酶活力,发现药物处理可导致DNA甲基化酶层析行为的改变,比活力增高。说明神方补肾生血药改变了大鼠肝DNA甲基化酶的分子结构,从而影响其比活力,这说明改变DNA甲基化酶,从而影响其DNA甲基化水平,可能是该药物抗衰老作用的机制之一。 |
英文摘要: |
An obvious anti-aging effect was found by Bushen Shengxue drug to treat Wistar rats. Using a method about incorporation of 3H-labled methyl group of S-adenosyl-methionine (SAM)into DNA bases, the DNA methylase activity was assayed.The specific activity of DNA methylase was increased by treatment of this drug. The chromatographic behaviour of DNA methylase from rat liver was also changed.These results showed that the mechanism of anti-aging effect of this drug is probably related to DNA methylation. |
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