中医药治疗难治性溃疡性结肠炎的临床研究

作者	单位
陈治水	中国人民解放军第２１１医院
聂志伟	中国人民解放军第２１１医院
孙旗立	中国人民解放军第２１１医院
王云翔	中国人民解放军第２１１医院
池勇	中国人民解放军第２１１医院
杜民	中国人民解放军第２１１医院
陶玉滨	中国人民解放军第２１１医院

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中文摘要:

对１５３例难治性溃疡性结肠炎随机分为３组，分别用健脾灵口服与苦参槐花合剂灌肠，柳氮磺胺吡啶（ＳＡＳＰ）口服与地塞米松灌肠，安慰剂口服与苦参槐花合剂灌肠。治疗９０天，３组治愈率分别为５３．１％、２７．７％和１９．０％，，总有效率分别为８５．９％、５９．６％和４５．２％（Ｐ＜０．００１）。提示健脾灵加苦参槐花合剂综合治疗方案疗效最佳。

英文摘要:

Clinical double blind study in treating 153 intractable ulcerative colitis with Chinese medicinal herbs was conducted,the patients were randomly assigned to three groups.Group I is administered with Jian Pi Ling(JPL)tablet with retention-enema of Radix Sophorae Flavescentis and Flos Sophora(RSF-FS)decoction per night,group Ⅱ with salicylazosulfapyridine(SASP)and retention-enema of dexamethasone,group Ⅲ with placebo and retention-enema of decoction as that in group Ⅰ.After 90 days every patients were checked by means of fibro-enteroscope,pathologic and immunologic parameters.The results:the curative rates of group Ⅰ,Ⅱ,Ⅲ,were 53.1%,27.7% and 19.0%,the total effetive rates were 85.9%,59.6% and 45.2% respectively.By comparison among groups,the efficacy of group Ⅰ was the best(P<0.01).The check of T and B lymphocyte subpopulation showed the B lymphocyte of group Ⅰmarkedly decreased,OKT3 and OKT8 obviously increased, the ratio of OKT4 and OKT8 approached normal value.The amount of IgG,IgM,C3 increased abnormally,decreased dramatically after medication, while those of group Ⅱ and Ⅲ have not changed significantly.The bacteriostatic test in vitro showed the bacteriostatic effect of RSF-FS on pathogenic B.coli,Shigella dysenteriae and Staphylococcus aureus was the best,that of solution Jian Pi Ling the next,that of SASP was the least effective.Therefore,the principle and method of group Ⅰ seems to be the best therapeutic programme.

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