槲寄生黄酮甙抗快速心律失常的细胞电生理研究

作者	单位
吴继雄	安徽医科大学附属第一医院心内科
俞国瑞	上海第二医科大学附属仁济医院心内科
王彬尧	上海第二医科大学附属仁济医院心内科
钟戴三	上海第二医科大学附属仁济医院心内科
黄定九	上海第二医科大学附属仁济医院心内科

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中文摘要:

采用细胞内玻璃微电极术观察了槲寄生黄酮甙（Ｖｉｓｃｕｍｃｏｌｏｒａｔｕｍｆｌａｖｏｎｏｉｄ，ＶＣＦ）对犬浦氏细胞及豚鼠心室肌细胞快反应动作电位（ＦＡＰ）的影响。结果表明：０．１ｍｇ／ｍｌ的ＶＣＦ加速ＦＡＰ复极化，使动作电位时程（ＡＰＤ）缩短（Ｐ＜０．０１），有效不应期（ＥＲＰ）缩短（犬Ｐ＜０．０５）或不变（豚鼠Ｐ＞０．０５）．但△ＥＲＰ／△ＡＰＤ比值增加。提示该药抗快速型心律失常的细胞电生理机制主要与其相对延长不应期，有利于中止折返有关。

英文摘要:

Viscum Coloratum Flavonoid (VCF) is one of the dihydro-flavonoids isolated and purified from the stem and leaf of Viscum Coloratum.It was proved both experimentally and clinically to have the effects of anti-tachyarrhythmias.The mechanism of this effect,however, was unclear.In this study,the effects of the drug on the fast response action potentials(FAP) in canine Purkinje fibers and guinea pig ventricular myocardial cells were investigated by glass-microelectrode technique.The results indicated that o.1mg/ml VCF accelerated the repolarizations of 2nd and 3rd phase of FAP,shortened action potential duration(APD),and slightly shortened effective refractory period(ERP)(canine) or unchanged(guinea pig).△ERP/△APD ratio was increased,therefore,ERP was relatively prolonged.All effects appeared after using the drug for 2 minutes, reached stable status after 10 minutes,and disappeared after washing off the drug for 15 minutes.It was suggested that VCF was the drug which exerted effects rapidly,maintained effects shortly,and had.effects reversibly.The cellular electrophysiologic mechanisms of VCF on anti-tachyarrhythmias should be attributed to prolong the ERP relatively and abolish the reentry.This drug is particularly applicable to the tachyarrhythmias due to reentry.

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