疔毒丸对胃肠平滑肌电活动与胃肠运动效应的影响

作者	单位
孙颂三	首都医学院
袁士琴	北京胸部肿瘤结核病研究所外科
唐玉	首都医学院
曲柏林	首都医学院
曲瑞瑶	首都医学院
曾文红	首都医学院

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中文摘要:

采用改进的整体同步记录方法，研究疔毒丸对胃肠平滑肌电活动及胃肠运动效应的影响。大鼠以３．５ｇ／ｋｇ灌胃可显著增加胃肠电慢波平均振幅、胃肠运动总振幅、肠电慢波频率和肠运动频率（Ｐ＜０．０５），但对胃电慢波频率和胃运动频率无明显影响（Ｐ＞０．０５）。小鼠以５．２ｇ／ｋｇ灌胃可显著促进肠套叠还纳作用。结果显示疔毒丸可增强肠电活动和肠运动，其程度明显大于对胃的作用。

英文摘要:

Dingduwan(DDW) is a Chinese herbal medicine.Method of modified synchronous recording was used to study the electric activities of gastrointestinal(GI) smooth muscle and the effect of GI motility treated by DDW.A dosage of 3.5g/kg for ingestion in rats markedly increased the average amplitude of GI slow wave,the total amplitude of GI motion,the rateof GI slow wave and intestinal motion(P<0.05),but it had no significant effects on the frequency of gastroelectric slow wave and gastric motility(P<0.05).DDW in the dosage of 5.2g/kg for ingestion markedly promoted the recovery of intestinal intussusception in mice(P>0.05).The results showed that DDW markedly increased the intestinal electricity and motility more than that of stomach.

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