大黄素对豚鼠离体肠管作用的影响

作者	单位
靳珠华	天津医学院药理教研室
马德录	天津医学院药理教研室
林秀珍	天津医学院药理教研室
李锡铭	天津医学院药理教研室

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中文摘要:

大黄素对豚鼠离体肠管的作用与剂量相关，＜２９．６μｍｏｌ／Ｌ时收缩作用随剂量增加而增强（Ｐ＜０．０１）；＞２９．６μｍｏｌ／Ｌ时，作用渐弱至停止。适当剂量的大黄素（１４．８μｍｏｌ／Ｌ）可使乙酰胆碱（Ａｃｈ）对豚鼠离体回肠和结肠的收缩作用比单用Ａｃｈ时均明显增强，其Ｐ值分别＜０．０５和０．０１，但增加大黄素剂量收缩作用反而渐弱，直至活动停止，此时再加入氯化钙（ＣａＣｌ２）０．２７ｍｍｏｌ／Ｌ又可恢复Ａｃｈ收缩肠管平滑肌的作用。实验表明：大黄素对豚鼠离体肠管具有双向调节作用并与钙离子的参与密切相关。

英文摘要:

Emodin is an active principle of Rheum palmatum.It is reported that emodin possesses antibiotic and antineoplastic functions.The effect of emodin action on the isolated intestinal smooth muscle of guinea-pigs were dose dependent.When the dose of emodin was less than 29.6μmol/L,the contraction effect enhanced obviously with increasing dosage;but whenever the dose increased to more than 29.6μmol/L,on the contrary,the effect decreased gradually and ceased finally.Emodin with appropriate concentration(14.8μmol/L) strengthened the effect of acetylcholine(Ach) on the isolated ileum and large intestine of guineapigs(P<0.05 and P<0.01).But high concentration of emodin could reduce even completely antagonize the effect of Ach.Under such condition,CaCl2 could restore the effect of Ach on the smooth muscle.It is suggested that emodin has biphasic regulatory effect on the intestinal smooth muscle,and its effect is related to calcium ion.

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