| 张秀珍,李素,吴先正,毕永昌,赵文杰,李宏光,吴伟科,韩春生.雷公藤多甙在胰岛移植治疗Ⅰ型糖尿病中的作用[J].中国中西医结合杂志,1994,(8):451-453 |
| 雷公藤多甙在胰岛移植治疗Ⅰ型糖尿病中的作用 |
| Effects of Tripterygiitotorum in Treating Insulin Dependant Diabetes Mellitus Patients with lslet Transplantation |
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| DOI： |
| 中文关键词: 雷公藤多甙 胰岛移植 T细胞亚群 |
| 英文关键词:Tripterygitotorum lslet transplantation T lymphocyte subpopulation |
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| 中文摘要: |
| 对３０例接受胰岛移植后服用雷公藤多甙（ＴⅡ）的Ⅰ型糖尿病患者（ＴⅡ组）与２４例胰岛移植后未应用任何免疫抑制剂的患者（对照组），分别在移植前及后１５天、１个月、６个月、１年检测外周血Ｔ细胞亚群、血清Ｃ肽，并与２０例健康人作对照。结果：移植前两组患者ＣＤ２、ＣＤ４均明显低于正常（Ｐ＜０．０１），ＣＤ４／ＣＤ８比值在１．２～２．０之间，移植后两组患者ＣＤ２、ＣＤ４均升高，ＴⅡ组接近正常（Ｐ＞０．０５），对照组ＣＤ４／ＣＤ８比值＞２．０。ＴⅡ组１９例胰岛素用量平均减少８４．２％，其中２例停用胰岛素；血清Ｃ肽水平峰值达３．２４±１．２ｎｇ／ｍｌ。对照组移植后６个月内与前者相仿（Ｐ＞０．０５），以后逐渐加大胰岛素用量，血清Ｃ肽亦下降，１年时接近术前状态（Ｐ＞０．０５）。提示ＴⅡ对胰岛移植具有免疫抑制功能，可延长移植物在受体内存活时间。 |
| 英文摘要: |
| The therapeutical efficacy of islet transplantation in treating insulin-dependant diabetes mellitus (IDDM) patients is marked for a short time and the long-term efficacy is unsatisfactory. So 30 IDDM patients given tripterygiitotorum(T Ⅱ) were compared with 24 IDDM patients without using any immunosuppressive agents after islet transplantation. Results: prior to transplantation both the numbers of T lymphocyte subpopulations such as CD2, CD4, CD8 and the concentrations of C-peptide in all IDDM patients were lowered, after transplantation the numbers of CD2,CD4 were significantly elevated (P<0.01), the ratio of CD4/CD8 in control group was higher than that in TⅡ group (p<0.01),while the concentration of C-peptide were greatly increased (normal: 2.24±0.34;before transplantation: 0.21±0.01; 15 days after transplantation: 3.24±1.2ng/ml).The peak value of C-peptide in TⅡ group began decreasing half a year after transplantation and it gradually dropped to the baseline level.The dose of insulin all were significantly reduced, and 3 patients stopped altogether.Half a year after transplantation TⅡ group remained stable for the requirement of insulin, whereas the control group gradually increased the dose of insulin.(1)Islet transplantation could adjust the immunological disorder in IDDM patients, increase the numbers of T lymphocyte subset such as CD2,CD4,CD8 while the chronic immuno-rejective response occurred.(2) TⅡinhibited both the numbers and function of T lymphocyte subpopulation and normalized the ratio of CD4/CD8.(3)TⅡ prolonged the survival time of grafts in IDDM patients and suppressed immunological rejection.(4) TⅡpreserved the therapeutical effects of Tripterygium wilfordii and minimizes itsside effects and toxicity. |
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