| 刘升明,汤泰秦.肺压宁治疗肺心病肺动脉高压的临床及实验研究[J].中国中西医结合杂志,1994,(8):469-473 |
| 肺压宁治疗肺心病肺动脉高压的临床及实验研究 |
| Clinical and Experimental Studies of Feiyaning in Treating Pulmonary Arterial Hypertension of Cor Pulmonale |
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| DOI： |
| 中文关键词: 益气活血 川芎嗪 肺心病 肺性高血压 缺氧 |
| 英文关键词:cor pulmonale pulmonary hypertension hypoxia ligustrazine Yiqi Huoxue |
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| 摘要点击次数: 1638 |
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| 中文摘要: |
| 本研究为用益气活血复方组成的肺压宁和川芎嗪治疗４０例慢性肺心病患者的临床观察，和防治急性低氧性肺动脉高压的实验研究。结果表明：肺压宁和川芎嗪均能扩张肺血管，降低肺动脉压和肺血管阻力，增加心输出量，改善心功能和血液流变性，抑制低氧性肺血管收缩，且肺压宁的效果优于川芎嗪。 |
| 英文摘要: |
| 40 Patients with chronic cor pulmonale(CCP) were treated with Feiyaning(FYN),a Yiqi Huoxue compound prescription,and ligustrazine(LT) were reported.The results showed that FYN and LT could lower the pulmonary artery pressure(PAP) significantly;decrease the pulmonary vascular resistance(PVR) as well as the consumption of oxygen in cardiac muscle; increase cardiac output(CO);improve some indices in hemorrheology,while PaO 2 and SaO2 didn’t change apparently.Moreover,lowering of FYN on PAP and PVR were superior to that of LT.The experimental studies showed that LT and injection of FYN could completely inhibit the hypoxia caused increase of PAP and PVR in rats;reduce the hypoxia caused pulmonary artery hypertension (PAH) and improve PVR of rats,as well as increase CO.The effects of FYN were superior to LT’s. Although LT and FYN could decrease systemic arterial pressure to certain extent, they didn’t induce systemic artery hypotension.It suggest that LT could reduce PAH definitely. |
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