大承气汤对胆囊切除术后胃肠激素及肠运动的影响

采用放免方法和肠鸣音分析技术观察了腹部术后胃肠激素改变和肠运动的关系及大承气汤对其的影响。结果显示，腹部术后肠道运动功能低下，肠管张力减低，运动不协调，与胃动素（ＭＯＴ）水平降低有关。大承气汤可促进肠管运动，增强肠管张力，血管活性肠肽、Ｐ物质、ＭＯＴ释放增加，生长抑素水平也升高。使消化道处于新的动态平衡，有利于术后消化功能的恢复。

英文摘要:

In order to elucidate the mechanism of postoperative intestinal dysfunction and the effects of Dachengqi Decoction(DCQD) on it,somatostatin(SS),gastrin(GAS),vasoactive intestinal polypeptide(VIP),substance P(SP),motilin(MOT) and atrial natriuretic peptide (ANP) were determined,frequency and spectrum of peristaltic sound were simultaneously analyzed in 31 subjects undergoing cholecystectomy,the value of pre-,post-operation and post-medication were compared.Plasma SS and MOT decreased postoperatively (P<0.05),DCQD elevated SS and MOT to higher level than preoperation,VIP,SP increased for half fold(P<0.05).Gurgling sound diminished after operation,whereas DCQD normalized it.Peak frequency(Fmax) of gurgling ranging from 234.4 to 468.2 Hz preoperatively,mean frequency(FA) was 341.8±30.9 Hz postoperatively.FA reduced to 322.3±79.4,DCQD elevated it to 374.2±57.1 Hz.The result suggested that intestinal motility was disturbed after cholecystectomy,bowel was in dystonic status,accompanying with decreased plasma MOT, DCQD promoted intestinal peristalsis and enhanced it’s tonus.The influence of gut peptides might be one of the important pathway that DCQD works.

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