宽叶缬草治疗冠心病的临床研究

作者用宽叶缬草挥发油（ＶＯＬ－Ｉ）治疗冠心病心绞痛甘情愿８２例（其中心肌缺血５０例），心绞痛症状疗效、心肌缺血疗效总有效率分别达８７．８０％、８８．００％对照组复方丹参注射液治疗心绞痛３４例（其中心肌缺血２４例），总有效率分别为４１．１８％、３７．５０％，两组比较差异有非常显著性（Ｐ＜０．００１，Ｐ＜０．０１）。本文研究还探讨了宽叶缬草的作用机理和临床应用特点，提示宽叶缬草是一种治疗冠心病的新型有效药物。

英文摘要:

Valeriana officinalis var latifolia(VOL),which is the variety of Valeriana officinalis and has the properties to relieve smooth muscle spasm and powerful vasodilation,as demonstrated by animal experiments,no report on its application in treating coronary heart disease(CHD) has been found as yet with VOL.Our preparation of a volatile oil fractionated from its root have been used to treat 82 CHD patients with anglna pectoris,among whom ST-T ischemic changes appeared on ECG in 50 cases before treatment.Its total effective rate for the simple angina(without detectable ischemicfinditings) was 87.80%,the angina with ischemic findings,88.00%.For comparisons,another 34 patients with the same conditions,24 cases among them belonged to the angina with ischemic findings,were treated with a composite injection of Salvia miltiorrhiza(SMCo),the total effective rates for the simple angina and for the angina with ischemic findings were 41.18% and 37.50% respectively.The differences between VOL and SMCo were both highly significant(p<0.001,p<0.01) either in the simple angina or in the angina with ischemic findings.The results showed VOL was superior to SMCo on matter in the remission of symptoms,decreasing the attack frequency and shortening the duration of angina,or in restoring the blood supply to ischemic myocaridium.In addition,it was discovered that VOL could lower plasma lipids as well.No toxic actions to liver,kidney,hemopoietic tissue,have been found.

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