鸦胆子油乳剂对家兔颅内压的影响

作者	单位
鲁继斌	中国医科大学附属第二医院胸外科
苏守元	中国医科大学附属第二医院胸外科
蔡际群	中国医科大学附属第二医院胸外科
金万宝	中国医科大学药理教研室
关福兰	中国医科大学药理教研室

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中文摘要:

本研究应用侧脑室插管连续描记颅内压方法，观察了中药鸦胆子油静脉乳剂及口服乳剂对家兔颅内压的影响。结果表明：鸦胆子油静脉乳剂具有较强的对抗硝普钠引起的颅内压升高作用（Ｐ＜０．０１），口服乳剂也有轻度拮抗颅内压升高作用；两种剂型对家兔正常颅内压及血压影响不大。这与鸦胆子乳剂可使肺癌脑转移引起的颅内压升高症状缓解的临床观察结果是一致的。

英文摘要:

Using the method of intubation into lateral cerebral ventricle, the effect of Burcea javanica oil emulsion(BJOE) venous emulsion and oral emulsion on rabbits with normal and intracranial hypertension respectively were observed, to study whether BJOE could reduce intracranial pressure or not. The results shown that venous emulsion of BJOE had strong action against the elevation of intracranial pressure produced by SNP p(P<0.01) while oral emulsion had mild action against it,which was similar to the clinical observation exhibiting improvement of clinical manifestions after application of BJOE on intracranial hypertension caused by brain metastasis from lung cancer.

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