固真方对老年大鼠胸腺细胞糖皮质激素受体作用的研究

本研究观察了固真方（含首乌、肉苁蓉、覆盆子等中药）对老年大鼠胸腺细胞糖皮质激素受体（ＧＣＲ）位点数和ＧＣＲ核转位率以及血清胸腺因子功能等的影响。结果表明：老年大鼠胸腺细胞ＧＣＲ位点数，胞浆蛋白、核ＲＮＡ和ＤＮＡ含量、胸腺重／体重比值以及血清胸腺因子功能均显著低于青年对照鼠，ＧＣＲ核转位率则明显高于青年对照鼠，而固真方能明显改善胸腺的上述老年性变化，提示固真方可能是通过抑制老年大鼠胸腺细胞ＧＣＲ由胞浆到核的转位活化能力，从而减弱糖皮质激素对胸腺的抑制作用，提高老年机体胸腺依赖性免疫功能。

英文摘要:

The effects of Guzhen Recipe(GZ)which composed of Polygonum multiflorum,Cistanche deserticole, Rubus chiagii etc,on the number of thymocyte glucocorticoid receptor (GCR) sites, the GCR nuclear translocation rate, and the activity of serum thymic factors etc in senile rats were observed. The results showed: The number of thymocyte GCR sites, the contents of cytoplasmic protein, nuclear RNA and DNA,the thymus weight/body weight ratio and the serum thymic factors in senile rats were significantly decreased, while thymocyte GCR nuclear translocation rate increased obviously than that of young control rats. GZ, however, was capable of improving the above-mentioned changes of thymus in senile rats markedly, suggesting that GZ might weaken the inhibitory effect of glucocorticoid on the thymus by means of suppressing the translocation activity of GCR from crtoplasm to nucleus in senile rats, thus enhance thymus-dependent immune function in senile rats.

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