固本益肠片治疗实验性豚鼠脾虚型溃疡性结肠炎的研究

作者	单位
王玉良	辽宁省中医研究院
谢杰	沈阳市康乐制药厂
李显华	辽宁省中医研究院
张宏	辽宁省中医研究院
温力平	沈阳市康乐制药厂
刘宗凯	大连海军４０６医院
邓晓梅	大连海军４０６医院

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中文摘要:

用２０％番泻叶浸剂灌服豚鼠，３天后肛门注入５％冰乙酸０．１ｍｌ，复制了辩证与辨病相结合的豚鼠脾虚型溃疡性结肠炎模型。造型动物出现的症状和病理改变与临床脾虚型溃疡性结肠炎疾病相一致。抗溃疡性结肠炎新药固本益肠片，灌胃给药７天，能使该模型脾虚症状减轻，促进体重恢复，结肠溃疡和水肿面积减少。

英文摘要:

Guinea pigs were perfused with the extract of senna(20%).3 days later glacial acetic acid (5%) was given intra-anally so as to replicate the animal model of Spleen Deficiency(SD) and ulcerative colitis which is the disease of Western medicine combined with the Syndrome in TCM. The model animals showed the symptoms of SD such as loose stool, anorexia, wasting, adversion of cold,laziness and loss of hair lustre and the symptoms of ulcerative colitis such as abdominal distension and mucous bloody stool.The colonic lesion were observed by eyes that the mucosa were edematous,congestive with ulcerative foci. The pathological examinations showed edema and congestion in submucous layers; large amount of inflammatory cell infiltration; and the scaling and ulcer formation of epithelium mucosae. The above-mentioned symptoms and pathological changes were the same as SD and ulcerative colitis in clinical practice. The new medicine "Guben Yichang Tablet"against ulcerative colitis was given to guinea pigs for 7 days could abate their spoptoms, increase their body weights and decrease the size of colonic ulcer and edema.

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