| 金锐,万玲玲,三石俊美,玉一惠,仓茂达德.紫华荣及其主要成分对丝裂霉素C所致小鼠免疫功能低下的预防作用[J].中国中西医结合杂志,1995,(2):101-103 |
| 紫华荣及其主要成分对丝裂霉素C所致小鼠免疫功能低下的预防作用 |
| Effects of Shi-ka-ron and Chinese Herbs in Mice Treated with Anti-Tumor Agent Mitomycin C |
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| DOI： |
| 中文关键词: 丝裂霉素C 巨噬细胞 T淋巴细胞 自然杀伤细胞 |
| 英文关键词:mitomycin C Shi-ka-ron macrophage T-lymphocyte natural killer cell |
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| 中文摘要: |
| 用抗癌药丝裂霉素Ｃ给小鼠腹腔内注射，同时口服中成药紫华荣及其主要成分紫草根、黄芪、川芎，以探讨中药对小鼠巨噬细胞和淋巴细胞的影响。结果丝裂霉素Ｃ能使小鼠腹腔内巨噬细胞数量减少，向异物的游走能力减慢，脾脏重量减轻，Ｔ淋巴细胞的母细胞化能力下降以及ＮＫ细胞的细胞毒作用减弱，并对巨噬细胞、Ｔ淋巴细胞的损害有防御作用。提示：紫华荣不但能刺激网状内皮系统使抑制状态的巨噬细胞恢复活性，也能使抑制的淋巴细胞活跃，对丝裂霉素Ｃ所造成的免疫不全现象起到积极的防御作用。 |
| 英文摘要: |
| The Shi-ta-Ron, and its constituent Chinese herbs Lithospermum erythrorkizon,Astragalus membranaceus and Ligusticum Walfichn were administered with antitumor agent, mitomycin C(MMC) to ICR mice,and their effects on murine macrophages and lymphocytes were studied.Peritoneal macrophages were significantly inhibited both in their number and chemotactic activity by MMC treatment.Splenic weight and blastogenic responsiveness to Concanavalin A of spleen lymphocytes also decreased significantly in MMC--treated mice. NK cell activity was also suppressed by MMC treatment. Then these mice were orally treated with extracts of Shi-ka-ron or each Chinese herbs mentioned above,it showed protective effects to immunosuppressive mice on all 5 items studied. The number of macrophages, and the functinos of macrophages and lymphocytes maintained the same or more than normal levels in MMC plus each group of these extracts treated mice.These results suggest that the Shi-Ka-Ron and Chinese herbs could resist immunosuppression induced by antitumor agent MMC, and its mechanisms might be correlated with stimulation of the RES (reticuloendothelial system), activation of T cell blastogenesis and NK cell cytotoxicity. |
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