| 金先桥,段生福,牛汝楫,张珍祥,徐永健.参麦注射液及其配伍对慢性缺氧鼠血气及血流动力学的影响[J].中国中西医结合杂志,1995,(3):162-164 |
| 参麦注射液及其配伍对慢性缺氧鼠血气及血流动力学的影响 |
| Effect of Shen Mai Injection and its Combinations on Blood Gas and Hemodynamics of Rats Exposed to Chronic Hypoxia |
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| DOI： |
| 中文关键词: 参麦注射液 缺氧 肺性高血压 扩张血管药物 |
| 英文关键词:Shen Mai Injection vasodilator hypoxia pulmonary hyper tension |
| 基金项目:国家八·五攻关基金 |
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| 中文摘要: |
| 参麦注射液是一种具有增强心肌与膈肌收缩功能的中药制剂。观察其对慢性缺氧鼠血气分析和血流动力学的影响发现，其可以显著降低慢性缺氧鼠的肺循环阻力（Ｐ＜０．００１）和体循环阻力（Ｐ＜０．００１），增加心输出量（Ｐ＜０．００１）；与扩张血管药物川芎嗪配伍应用的效果较其他配伍效果要好。表明参麦注射液及其和川芎嗪的配伍应用在治疗肺动脉高压合并隔肌疲劳中有一定应用价值。 |
| 英文摘要: |
| Shen Mai Injection (SMI) consisted of Panax ginseng and Ophiopogon japonica might promote the myocardial and diaphragmatic muscle contraction. The effect of SMI and its combinations were examined on the blood gas and hemodynamics of rats exposed to chronic hypoxia. SMI reduced significantly the pulmonary vascular resistance (PVR,P<0.001), systemic vascular resistance (SVR, P<0.001) and increased cardiac output (CO, P<0.001), which effect was superior to the Dobutamine. If SMI was combined with Ligustrazine etc, better effect on blood gas and hemodynamics appeared than that of combined with other drugs. These combined group also presented more selective on pulmonary circulation. The results suggested that SMI and its combined with Ligustrazine could relieve the pulmonary hypertension and diaphragmatic fatigue. |
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