| 陈敏光,王其豪,林玉冰,陈孔利,林华阳,林玮,林芩,刘飞.高乌甲素硬膜外注射术后镇痛的临床研究[J].中国中西医结合杂志,1995,(5):274-276 |
| 高乌甲素硬膜外注射术后镇痛的临床研究 |
| Clinical Study in Epidural injection with Lappaconitine for Post-operative Analgesia |
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| DOI： |
| 中文关键词: 高乌甲素 吗啡 硬膜外腔 术后镇痛 |
| 英文关键词:Lappaconitine morphine epidural space post-operative analgesia |
| 基金项目:福建省教委科技三项费用资助 |
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| 中文摘要: |
| 本研究观察了高乌甲素硬膜外腔注射术后镇痛的效能和副作用。患者５０例随机分为５组，Ａ、Ｂ、Ｃ３组为观察组，分别用高乌甲素４ｍｇ、８ｍｇ、１２ｍｇ；Ｄ、Ｅ两组为对照组，分别用生理盐水６ｍｌ和吗啡２ｍｇ，于手术结束时将药液注入硬膜外腔。结果：５组镇痛的疗效和维持时间顺序为Ｅ组＞Ｃ组＞Ｂ组＞Ａ组＞Ｄ组，其中Ｃ组能达到患者有效镇痛的基本要求，其镇痛效能虽不及Ｅ组的吗啡，但无吗啡的不良反应。表明应用高乌甲素行术后镇痛是有效和安全的。 |
| 英文摘要: |
| This paper studied the effect and side-effect of Lappaconitine for post-operative analgesia with epidural injection. 50 patients who were operated in the upper abdomen with epidural anesthesia.These patients were randomly divided into 5 groups. The general condition of every group was similar.Group A,B,C was given Lappaconitine 4ml, 8ml,12ml individually for observation. Group D, E was given 0 .9% NS 6 ml and morphine 2mg individually as control. When the operation was finished the drug was injected into the epidural space with single blind method.The result showed the analgesia of the drug and its effective time was: group E>C>B>A>D.The analgesic effect of Group C was satisfactory. The efficacy and the maintenance time of A, B, C groups were significantly different from that of group D(P<0.05,P<0.01).Although the effect of group C was less potent than that of group E(morphine injection),there was no side-effect as morphine had. Itsuggested that Lappaconitine for post-operative analgesia with epidural injection is effective and safe. |
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