慢性特发性血小板减少性紫癜免疫学改变和中医辨证分型与预后关系初步分析

Preliminary Analysis of Relationship between Immunological Changes and Syndrome Differentiation-Typing in Traditional Chinese Medicine and Prognosis with Chronic Idiopathic Thrombocytopenic Purpura

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DOI：

中文关键词: 血小板减少性紫癜淋巴细胞亚群血小板抗体中医辨证分型预后

英文关键词:thrombocytopenic purpura lymphocyte subsets platelet-antibodies Syndrome Differentiation-Typing of traditional Chinese medicine prognosis

基金项目:

作者	单位
杨宇飞	中国中医研究院西苑医院血液病研究室
周霭祥	中国中医研究院西苑医院血液病研究室
麻柔	中国中医研究院西苑医院血液病研究室

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中文摘要:

应用ＡＰＡＡＰ桥联酶标技术和双抗夹心ＥＬＩＳＡ法，测定了５５例慢性特发性血小板减少性紫癜（ＩＴＰ）患者和２５名健康对照者外周血Ｔ淋巴细胞亚群、２８名健康对照者血小板相关抗体ＰＡＩｇＧ、ＰＡＩｇＡ、ＰＡＩｇＭ和血浆抗血小板膜糖蛋白（ＧＰ）Ⅱｂ、ＧＰⅢａ、ＧＰⅠｂ自身抗体；分析了治疗前上述免疫学改变及中医辩证分型与预后的关系。发现免疫学改变与预后关系密切，中医证型与预后也有一定关系。提示ＩＴＰ治疗前免疫指标水平及中医证型对于判定预后、指导治疗有一定意义。

英文摘要:

In order to study the relationship between the basement immunological changes,TCM Syndrome Differentiation and prognosis,alkaline phosphates antialkaline phosphatase(APAAP) and ELISA assay were used to determine the T lymphocyte subsets,the platelet associated antibody(PAIgG,PAIgA,PAIgM) and plasma antiplatelet-autoantibodies(GPⅡ b,GPⅢ a,GP Ⅰ b) in 55 chronic idiopathic thrombocytopenic purpura(ITP) and.53 healthy subjects as control.The results indicated that the immunological changes was closely related to the prognosis,while the TCM Syndrome Differentiation was also related to it,which denoted that it is significant to investigate both factors in guiding treatment and assessing the prognosis.

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