茯苓对豚鼠卡那霉素中毒性耳聋的对抗作用

作者	单位
刘耀春	山东潍坊医学院
刘桂英	山东潍坊医学院
刘儒林	山东潍坊医学院
程秀臻	山东潍坊医学院
李宁	山东潍坊医学院
候建平	山东潍坊医学院

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中文摘要:

为了更好地预防卡那霉素中毒性耳聋的发生，通过给豚鼠灌服茯苓煎剂，以一般中毒症状、耳廓反射阈、脑干听觉诱发电位阈及外毛细胞缺失率为指标，观察了茯苓对卡那霉素中毒性耳损害的影响。结果发现服用茯苓煎剂可明显减轻卡那霉素耳损害，服药组和未服药组动物的４ｋＨｚ、６ｋＨｚ、８ｋＨｚ的耳廓反射阈在用药第７天时分别为４．７±１．５ｄＢ、５．７±２．４ｄＢ、２．７±１．２ｄＢ和１０．５±３．２ｄＢ、１２．１±３．７ｄＢ、８．５±２．７ｄＢ。脑干听觉诱发电位阈分别较实验前升高２２．７±９．７ｄＢ和５１．３±１４．４ｄＢ。柯蒂氏器底圈外毛细胞缺失率分别为３９．４％和６７．４％。表明茯苓对卡那霉素中毒性耳损害有对抗作用。

英文摘要:

In order to prevent the ototoxicity of kanamycin(KM),the effects of Poria Cocos(PC) on the ototoxicity induced by KM in guinea-pigs was observed by infusing the PC decoction into the guineapigs with comparing the difference in the general intoxicating symptom,prayer’s reflex(PR)threshold,brainstem auditory evoked potentials(BAEPs) and the absence rate of outer hair cells in the first turn of cochlea.The results suggested that the ototoxicity of KM was retarded by giving the PC decoction.On 7th day after given KM,PR threshold of 4,6,8 kHz in the medicated group and control group were 4.7±1.5dB,5.7±2.4dB,2.7±1.2dB and 10.5±3.2dB,12.1±3.7dB,8.5±2.7dB respectively.BAEPs threshold on 13th day given KM raised 22.7±9.7dB in the medicated group and 51.3±14.4dB in control group.The absence rate of outer hair cells in first turn of cochlea were 39.4% and 67.4% respectively.The results suggested that PC might be antagonistic to the ototoxicity of KM in guinea-pigs.

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