| 吕崇山,张铁忠,张惠铭,史载祥,赵静波,王泰玲,王跃,武泽民.通脉降脂口服液抗动脉粥样硬化作用的实验研究[J].中国中西医结合杂志,1995,(8):479-482 |
| 通脉降脂口服液抗动脉粥样硬化作用的实验研究 |
| Experimental Study on Anti-Atherosclerotic Effect of Tongmai Jiangzhi Oral Liquor |
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| DOI： |
| 中文关键词: 通脉降脂口服液 动脉粥样硬化 血脂过多 过氧化脂质 血栓素B2 |
| 英文关键词:Tongmai Jiangzhi oral liquor atherosclerosis hyperlipidemia lipid peroxidation prostaglandin |
| 基金项目:国家八·五科技攻关资助 |
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| 摘要点击次数: 1598 |
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| 中文摘要: |
| 将日本大耳白兔２７只随机分为３组，观察中药通脉降脂口服液在实验性动脉粥样硬化形成中降低血脂、减轻脂质过氧化损伤、调节前列腺素代谢及减轻粥样斑块形成作用。结果表明：通脉降脂口服液可明显地降低实验动物血清胆固醇（ＴＣ）、甘油三酯（ＴＧ）、血浆脂质过氧化物（ＬＰＯ）及血栓素Ｂ２（ＴＸＢ２）的含量，升高全血谷胱甘肽过氧化物酶（ＧＳＨ－ｐＸ）活性，调节血栓素Ｂ２／６－酮－前列环素(６－ｋｅｔｏ－ＰＧＦｌａ)的平衡，并可使主动脉粥样硬化斑块面积及厚度明显小于胆固醇组。通脉降脂口服液的上述作用可能是其抗动脉粥样硬化作用的主要机制。 |
| 英文摘要: |
| Japanese white male rabbits were divided into 3 groups for evaluation of Tongmai Jiangzhi Oral Liquor(TMJZ)in reducing the serum cholesterol,the level of plasma lipid peroxidation(LPO),the plasma TXB 2 and suppressing of atherosclerotic plaque formation in atherogenesis.The results indicated that TMJZ not only decreased significantly the levels of serum cholesterol,triglyceride,LPO and TXB 2,but also increased markedly blood glutathion peroxidase(GSH-Px) activity and regulated the balance of TXB2/6-keto-PGF la. The area of atherosclerotic plaque coverage in aorta and the thickness of plaque after oral TMJZ were much smaller than those of high -cholesterol-fed rabbits.It is suggested that the effect of TMJZ on above-mentioned indexes might be important mechanism of its anti-atherosclerotic effect. |
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